Nutrition Research
Volume 21, Issue 1 , Pages 183-189 , January 2001

Probiotic supplementation to enhance natural immunity in the elderly: effects of a newly characterized immunostimulatory strain Lactobacillus rhamnosus HN001 (DR20™) on leucocyte phagocytosis

  • Harsharnjit S Gill

      Affiliations

    • Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand
    • Corresponding Author InformationTel.: +64-6-350-6104; fax: +64-6-350-5446
    • ,
  • Kay J Rutherfurd

      Affiliations

    • Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand

Received 6 November 2000 ,Accepted 6 November 2000.

References 

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  3. Lesourd BM. Nutrition and immunity in the elderly (modification of immune responses with nutritional treatments). Am J Clin Nutr. 1997;66:478S–484S
  4. Bounous G, Kongshavn PAL, Gold P. The immunoenhancing property of dietary whey protein concentrate. Clin Invest Med. 1988;11:271–278
  5. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet. 1992;340:1124–1127
  6. Pike J, Chandra RK. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vit Nutr Res. 1995;65:117–121
  7. Gogos CA, Ginopoulos P, Zoumbos NC, Apostolidou E, Kalfarentzos F. The effect of dietary omega-3 polyunsaturated fatty acids on T-lymphocyte subsets of patients with solid tumors. Cancer Detect Prevent. 1995;19:415–417
  8. Senkal M, Kemen M, Homann HH, Eickhoff U, Baier J, Zumtobel V. Modulation of postoperative immune response by enteral nutrition with a diet enriched with arginine, RNA, and omega-3 fatty acids in patients with upper gastrointestinal cancer. Eur J Surg. 1995;161:115–122
  9. Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H. Enhancement of the circulating antibody secreting cell response in human diarrhoea by a human Lactobacillus strain. Pediatr Res. 1992;32:141–144
  10. Isolauri E, Joensus J, Suomalainen H, Luomala M, Vesikari T. Improved immunogenicity of oral D XRRV reabsorbant rotavirus vaccine by Lactobacillus casei GG. Vaccine. 1995;13:310–312
  11. Schiffrin EJ, Rochar F, Link-Amster H. Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J Dairy Sci. 1995;78:491–497
  12. Kishi A, Uno K, Matsubara Y. Effect of the oral administration of Lactobacillus brevis subsp. coagulans on interferon-α producing capacity in humans. J Am Coll Nutr. 1996;15:408–412
  13. Donnet-Hughes A, Rochat F, Serrant P. Modulation of nonspecific mechanisms of defense by lactic acid bacteria (effective dose). J Dairy Sci. 1999;82:863–869
  14. Arunachalam K, Gill HS, Chandra RK. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr. 2000;54:1–5
  15. Prasad J, Gill HS, Smart J, Gopal P. Selection and characterisation of Lactobacillus and Bifidobacterium strains for use as probiotics. Int Dairy J. 1999;8:993–1002
  16. Gill HS. Stimulation of the immune system by lactic cultures. Int Dairy J. 1998;8:535–544
  17. Gill HS, Rutherfurd KJ, Prasad J, Gopal PK. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Brit J Nutr. 2000;83:167–176
  18. Chiang B-L, Sheih Y-H, Wang L-H, Liao C, Gill HS. Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimisation and definition of cellular immune responses. Eur J Clin Nutr 2000;54:849–855.
  19. Hessle C, Hanson LA, Wold AE. Lactobacilli from human gastrointestinal mucosa are strong stimulators of IL-12 production. Clin Exp Immunol. 1999;116:276–282
  20. Miettinen M, Matikeinen S, Vuopio-Varkila J, Pirhonen J, Varkila K, Kurimoto M, et al. Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18 and gamma-interferon production in human peripheral blood mononuclear cells. Infect Immun. 1999;66:6058–6062
  21. Goodwin JS. Decreased immunity and increased morbidity in the elderly. Nutr Rev. 1995;53(II):S41–S45
  22. Weksler ME. Immune senescence (deficiency or dysregulation?). Nutr Rev. 1995;53(II):S3–S7
  23. Macfarlane GT, Cummings JH. Probiotics and prebiotics (can regulating the activities of intestinal bacteria benefit health?). Brit Med J. 1999;318:999–1003
  24. Meydani SN, Ha WK. Immunologic effects of yogurt. Am J Clin Nutr. 2000;71:861–872

PII: S0271-5317(00)00294-3

doi: 10.1016/S0271-5317(00)00294-3

Nutrition Research
Volume 21, Issue 1 , Pages 183-189 , January 2001

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