Nutrition Research
Volume 23, Issue 1 , Pages 35-44 , January 2003

Oral arginine has no acute effect on blood glucose concentrations or glucose production in type 2 diabetic volunteers

  • Roslyn Chaisanguanthum

      Affiliations

    • Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
    • ,
  • John A. Tayek

      Affiliations

    • Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-310-222-1237; fax: +1-310-320-8459.

Received 10 April 2002 ,Revised 9 August 2002 ,Accepted 15 August 2002.

References 

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  2. Wascher TC, Graier WF, Dittrich P, Hussain MA, Bahadorl B, Wallner S, et al. Effects of low-dose l-arginine on insulin-mediated vasodilation and insulin sensitivity. Eur J Clin Invest. 1997;27:690–695
  3. Stadler J, Barton D, Beil-Moeller H, Diekmann S, Hierholzer C, Erhard W, et al. Hepatocyte nitric oxide biosynthesis inhibits glucose output and competes with urea synthesis of l-arginine. Am Phys Soc. 1995;268:G183–188
  4. Kahn NN, Acharya K, Bhattacharya S, Acharya R, Mazumder S, Bauman WA, et al. Nitric oxide (the second messenger of insulin). Life. 2000;49:441–450
  5. Piatti P, Monti LD, Valsecchi G, Magni F, Setola E, Marchesi F, et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 2001;24:875–880
  6. Das UN, Mohan IK, Kumar KV, Kumar GS, Sekhar CC. Beneficial effect of l-arginine in non-insulin dependent diabetes mellitus (a potential role for nitric oxide). Med Sci Res. 1993;21:669–670
  7. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes. Its potential role in nitric oxide generation. J Clin Nutr. 2000;21(5):422–427
  8. Chhibber VL, Soriano C, Tayek JA. Effects of low-dose and high dose glucagon on glucose production and gluconeogenesis in humans. Metabolism. 2000;49:39–46
  9. Egan JM, Henderson TE, Bernier M. Arginine enhances glycogen synthesis in response to insulin in 3T3-L1 adipocytes. Am J Physiol. 1995;269:E61–66
  10. Wu G, Morris SM. Arginine metabolism (nitric oxide and beyond). Biochem J. 1998;336:1–17
  11. Meininger CJ, Marinos RS, Hatakeyama K, Martinez-Aaguilan R, Rojas JD, Kelly KA, et al. Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency. Biochem J. 2000;349:353–356
  12. Honing MLH, Morrison PJ, Banga JD, Stroes ESG, Rabelink TJ. Nitric oxide availability in diabetes mellitus. Diabetes Metab Rev. 1998;14:241–249
  13. Pieper GM, Dondlinger LA. Plasma and vascular tissue arginine are decreased in diabetes (acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production). J Pharm Exp Ther. 1997;283:684–691
  14. Trachtman H, Futterweit S, Crimmins DL. High glucose inhibits nitric oxide production in cultured rat mesangial cells. J Am Soc Nephrol. 1997;8(8):1276–1282
  15. Shinozaki K, Kashiwagi A, Nishio Y, Okamura T, Yoshida Y, Masada M, et al. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta. Diabetes. 1999;48:2437–2445
  16. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res. 2001;88:e14–22

PII: S0271-5317(02)00481-5

Nutrition Research
Volume 23, Issue 1 , Pages 35-44 , January 2003

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