Nutrition Research
Volume 23, Issue 1 , Pages 117-122, January 2003

Reduction of aberrant crypt foci by ingestion of polydextrose in the rat colorectum

  • Satoshi Ishizuka

      Affiliations

    • Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-11-706-2504; fax: +81-11-706-2504.
    • ,
  • Takumi Nagai

      Affiliations

    • College of Medical Technology, Hokkaido University, Sapporo 060-0812, Japan
    • ,
  • Hiroshi Hara

      Affiliations

    • Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan

Received 1 March 2002; received in revised form 20 August 2002; accepted 31 August 2002.

Abstract 

To investigate the effect of dietary polydextrose on development of aberrant crypt foci (ACF), we fed rats with polydextrose-containing diet in various timing before or after 1,2-dimethylhydrazine (DMH) injection and measured ACF parameters. Every parameter for ACF was significantly reduced in the rats fed polydextrose from day 7 before DMH injection than in the fiber-free diet fed rats. This study shows that ingestion of polydextrose has protective effect on ACF especially in the rectum and the timing of dietary treatment is critical for inhibition of ACF development.

Keywords: Polydextrose, Aberrant crypts, 1,2-dimethylhydrazine

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PII: S0271-5317(02)00485-2

Nutrition Research
Volume 23, Issue 1 , Pages 117-122, January 2003

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