Nutrition Research
Volume 23, Issue 1 , Pages 117-122 , January 2003

Reduction of aberrant crypt foci by ingestion of polydextrose in the rat colorectum

  • Satoshi Ishizuka

      Affiliations

    • Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-11-706-2504; fax: +81-11-706-2504.
    • ,
  • Takumi Nagai

      Affiliations

    • College of Medical Technology, Hokkaido University, Sapporo 060-0812, Japan
    • ,
  • Hiroshi Hara

      Affiliations

    • Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan

Received 1 March 2002 ,Revised 20 August 2002 ,Accepted 31 August 2002.

References 

  1. Bird RP. Observation and quantification of aberrant crypt in the murine colon treated with a colon carcinogen (preliminary findings). Cancer Lett. 1987;37:147–151
  2. Pletlow TP, Cheyer C, O’Riordan MA. Aberrant crypt foci and colon tumors in F344 rats have similar increases in proliferative activity. Int J Cancer. 1994;56:599–602
  3. Otori K, Sugiyama K, Hasebe T, Fukushima S, Esumi H. Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation. Cancer Res. 1995;55:4743–4746
  4. Shivapurkar N, Tang ZC, Alabaster O. The effect of high-risk and low-risk diets on aberrant crypt and colonic tumor formation in Fischer-344 rats. Carcinogenesis. 1992;13:887–890
  5. Pletlow TP, Roukhadze EV, O’Riordan MA, Chan JC, Amini SB, Stellato TA. Carcinoembryonic antigen in human colonic aberrant crypt foci. Gastroenterology. 1994;107:1719–1725
  6. Ishizuka S, Ito S, Onuma M, Kasai T, Aoyama Y, Hara H. Ingestion of sugar beet fiber enhances irradiation-induced aberrant crypt foci in the rat colon under an apoptosis-suppressed condition. Carcinogenesis. 1999;20:1005–1009
  7. Nagai T, Ishizuka S, Hara H, Aoyama Y. Dietary sugar beet fiber prevents the increase in aberrant crypt foci induced gamma-irradiation in the colorectum of rats treated with an immunosuppressant. J Nutr. 2000;130:1682–1687
  8. Ishizuka S, Kasai T. Suppression of the number of aberrant crypt foci of rat colorectum by ingestion of sugar beet fiber regardless of administration of anti-asialo GM1. Cancer Lett. 1997;121:39–43
  9. Hara H, Suzuki T, Kasai T. Ingestion of the soluble dietary fibre, polydextrose, increases calcium absorption and bone mineralization in normal and total-gastrectomized rats. Br J Nutr. 2000;84:655–661
  10. Ogata S, Fujimoto K, Iwakiri R, Matsunaga C, Ogawa Y, Koyama T, et al. Effect of polydextrose on absorption of triglyceride and cholesterol in mesenteric lymph-fistula rats. Proc Soc Exp Biol Med. 1997;215:53–58
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  14. Perrin P, Cassagnau C, Burg C, Patry Y, Vavasseur F, Harb J, et al. An interleukin 2/sodium butyrate combination as immunotherapy for rat colon cancer peritoneal carcinomatosis. Gastroenterology. 1994;107:1697–1708
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PII: S0271-5317(02)00485-2

Nutrition Research
Volume 23, Issue 1 , Pages 117-122 , January 2003

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