Nutrition Research
Volume 23, Issue 1 , Pages 103-109 , January 2003

The impact of α-tocopherol on radiation-induced liver injury

  • K Kotzampassi

      Affiliations

    • Department of Surgery, Faculty of Medicine, AHEPA Hospital University of Thessaloniki, Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30-310-933496; fax: +30-310-993496.
    • ,
  • D Paramythiotis

      Affiliations

    • Department of Surgery, Faculty of Medicine, AHEPA Hospital University of Thessaloniki, Thessaloniki, Greece
    • ,
  • K Tsiakitzis

      Affiliations

    • Department of Pharmaceutical Chemistry, Faculty of Pharmaceutics, University of Thessaloniki, Thessaloniki, Greece
    • ,
  • A.P Kourounakis

      Affiliations

    • Department of Pharmaceutical Chemistry, Faculty of Pharmaceutics, University of Thessaloniki, Thessaloniki, Greece
    • ,
  • J Tzitzikas

      Affiliations

    • Department of Radiation Oncology, AHEPA Hospital University of Thessaloniki, Thessaloniki, Greece
    • ,
  • G Metaxas

      Affiliations

    • Department of Surgery, Faculty of Medicine, AHEPA Hospital University of Thessaloniki, Thessaloniki, Greece
    • ,
  • P.N Kourounakis

      Affiliations

    • Department of Pharmaceutical Chemistry, Faculty of Pharmaceutics, University of Thessaloniki, Thessaloniki, Greece
    • ,
  • N Harlaftis

      Affiliations

    • Department of Surgery, Faculty of Medicine, AHEPA Hospital University of Thessaloniki, Thessaloniki, Greece
    • ,
  • E Eleftheriadis

      Affiliations

    • Department of Surgery, Faculty of Medicine, AHEPA Hospital University of Thessaloniki, Thessaloniki, Greece

Received 26 April 2002 ,Revised 29 August 2002 ,Accepted 2 September 2002.

References 

  1. Lawrence TS, Robertson JM, Anscher MS, Jirtle RL, Ensminger WD, Fajardo LF. Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys. 1995;31:1237–1248
  2. Sempoux C, Horsmans Y, Geubel A, Fraikin J, Van Beers BE, Gigot JF, et al. Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma (activation of hepatic stellate cells as an early event). Hepatology. 1997;26:128–134
  3. Panes J, Granger DN. Neutrophils generate oxygen free radicals in rat mesenteric microcirculation after abdominal irradiation. Gastroenterology. 1996;111:981–989
  4. Shulman HM, Gown AM, Nugent DJ. Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules. Am J Pathol. 1987;127:549–558
  5. Empey LR, Papp JD, Jewell LD, Fedorak RN. Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis in rats. Dig Dis Sci. 1992;37:205–214
  6. Erbil Y, Dibekoglu C, Turkoglu U, Ademoglu E, Berber E, Kizir A, et al. Nitric oxide and radiation enteritis. Eur J Surg. 1998;164:863–868
  7. Gurbuz AT, Kunzelman J, Ratzer EE. Supplemental dietary arginine accelerates intestinal mucosal regeneration and enhances bacterial clearance following radiation enteritis in rats. J Surg Res. 1998;74:149–154
  8. Ersin S, Tuncyurek P, Esassolak M, Alkanat M, Buke C, Yilmaz M, et al. The prophylactic and therapeutic effects of glutamine- and arginine-enriched diets on radiation-induced enteritis in rats. J Surg Res. 2000;89:121–125
  9. Geraci JP, Mariano MS, Jackson KL. Radiation hepatology of the rat (time-dependent recovery). Radiat Res. 1993;136:214–221
  10. Weiss JF, Landauer MR. Radioprotection by antioxidants. Ann N Y Acad Sci. 2000;899:44–60
  11. Kennedy M, Bruninga K, Mutlu EA, Losurdo J, Choudhary S, Keshavarzian A. Successful and sustained treatment of chronic radiation proctitis with antioxidant vitamins E and C. Am J Gastroenterol. 2001;96:1080–1084
  12. Mutlu-Turkoglu U, Erbil Y, Oztezcan S, Olgac V, Toker G, Uysal M. The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats. Life Sci. 2000;66:1905–1913
  13. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–358
  14. Vajragupta O, Toasaksiri S, Boonyarat C, Wongkrajang Y, Peungvicha P, Watanabe H, et al. Chroman amide and nicotinyl amide derivatives (inhibition of lipid peroxidation and protection against head trauma). Free Radic Res. 2000;32:145–155
  15. Lowry OH, Rosenbrough NJ, Farr YL, Randall A. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265–275
  16. Mittur AV, Kaplowitz N, Kempner ES, Ookhtens M. Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation. Am J Physiol. 1998;274:G923–930
  17. Akerboom TP, Bilzer M, Sies H. The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver. J Biol Chem. 1982;257:4248–4252
  18. Wang X, Quinn PJ. Vitamin E, and its function in membranes. Prog Lipid Res. 1999;38:309–336
  19. Yoshida S, Busto R, Santiso M, Ginsberg MD. Brain lipid peroxidation induced by postischemic reoxygenation in vitro (Effect of vitamin E). J Cereb Blood Flow Metab. 1984;4:466–469
  20. Hall ED, Wolf DL. A pharmacological analysis of the pathophysiological mechanisms of post-traumatic spinal cord ischemia. J Neurosurg. 1986;64:951–961
  21. Hall ED, Braughler JM. Role of lipid peroxidation in post-traumatic spinal cord degeneration (A review). CNS Trauma. 1987;3:281–294
  22. Navarro J, Obrador E, Pellicer JA, Aseni M, Vina J, Estrela JM. Blood glutathione as an index of radiation-induced oxidative stress in mice and humans. Free Radic Biol Med. 1997;22:1203–1209

PII: S0271-5317(02)00488-8

Nutrition Research
Volume 23, Issue 1 , Pages 103-109 , January 2003

Article Tools

* Image Usage & Resolution