Nutrition Research
Volume 23, Issue 9 , Pages 1221-1228 , September 2003

Supplementation with fruit and vegetable concentrate decreases plasma homocysteine levels in a dietary controlled trial

  • Michele F. Panunzio

      Affiliations

    • Section of Human Nutrition, Department of Health, Local Healthcare Unit Foggia, Piazza Pavoncelli n. 11, 71100 Foggia, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-881-732-933; fax: +39-881-732-929.
    • ,
  • Alessandra Pisano

      Affiliations

    • Section of Human Nutrition, Department of Health, Local Healthcare Unit Foggia, Piazza Pavoncelli n. 11, 71100 Foggia, Italy
    • ,
  • Antonietta Antoniciello

      Affiliations

    • Section of Human Nutrition, Department of Health, Local Healthcare Unit Foggia, Piazza Pavoncelli n. 11, 71100 Foggia, Italy
    • ,
  • Vincenzo Di Martino

      Affiliations

    • Section of Human Nutrition, Department of Health, Local Healthcare Unit Foggia, Piazza Pavoncelli n. 11, 71100 Foggia, Italy
    • ,
  • Lucia Frisoli

      Affiliations

    • Section of Human Nutrition, Department of Health, Local Healthcare Unit Foggia, Piazza Pavoncelli n. 11, 71100 Foggia, Italy
    • ,
  • Vincenzo Cipriani

      Affiliations

    • Section of Human Nutrition, Department of Health, Local Healthcare Unit Foggia, Piazza Pavoncelli n. 11, 71100 Foggia, Italy
    • ,
  • Maria A. Mongelli

      Affiliations

    • Aesculapius Laboratory, Viale Telesforo-71100 Foggia, Italy
    • ,
  • Giorgio Bronzetti

      Affiliations

    • National Council of Research–Pisa, Italy

Received 3 February 2003 ,Revised 8 June 2003 ,Accepted 11 June 2003.

References 

  1. Heber D, Bowerman S. Applying science to changing dietary patterns. J Nutr. 2001;131:3078S–3081S
  2. Messina M, Lampe JW, Birt DF, Appel LJ, Pivonka E, Berry B, et al. Reductionism and the narrowing nutrition perspective (time for reevaluation and emphasis on food synergy). J Am Diet Assoc. 2001;101:1416–1419
  3. Trobs M, Renner T, Scherer G, Heller WD, Geiss HC, Wolfram G, et al. Nutrition, Antioxidants, and Risk Factor Profile of Nonsmokers, Passive Smokers and Smokers of the Prevention Education Program (PEP) in Nuremberg, Germany. Prev Med. 2002;34:600–607
  4. Hermann W. The importance of hyperomocysteinemia as a risk factor for deseases (an overview). Clin Chem Lab Med. 2001;39:666–674
  5. Sasaki T, Watanabe M, Nagai Y, Hoshi T, Takasawa M, Nukata M, et al. Association of Plasma Homocysteine Concentration With Atherosclerotic Carotid Plaques and Lacunar Infarction. Stroke. 2002;33:1493–1496
  6. Sanchez Bayle M. Homocysteine as a cardiovascular risk factor. An Esp Pediatr. 2002;56:399–401
  7. Ducloux D, Motte G, Massy ZA. Hyperhomocyst(e)inemia as a risk factor after renal transplantation. Ann Transplant. 2001;6:40–42
  8. Myers KA. Elevated homocysteine (a new marker for dementia?). CMAJ. 2002;166:1068
  9. Nilsson K, Gustafson L, Hultberg B. Relation between Plasma Homocysteine and Alzheimer's Disease. Dement Geriatr Cogn Disord. 2002;14:7–12
  10. Malinow RM. Plasma concentrations of total homocysteine predict mortality risk. Am J Clin Nutr. 2001;74:3
  11. Vollset SE, Refsum H, Tverdal A, Nygård O, Nordrehaug JE, Tell GS, et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality (the Hordaland Homocysteine Study). Am J Clin Nutr. 2001;74:130–136
  12. Clarke R, Woodehouse P, Ulvik A, et al.  Variability and determinants of total homocysteine concentrations in plasma. Clin Chem. 1998;44:102–107
  13. Garg UC, Zheng Z-J, Folsom AR, et al.  Short-term, and long-term variability of plasma homocysteine measurement. Clin Chem. 1997;43:141–145
  14. Moustapha A, Robinson K. Homocysteine (An emerging age-related cardiovascular risk factor). Geriatrics,. 1999;4:12–15
  15. Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217–246
  16. Finkelstein JD. The metabolism of homocysteine (pathways and regulation). Eur J Pediatr. 1998;157:S40–S44
  17. Jacobsen DW. Biochemistry and Metabolism. In:  Robinson K editors. Homocysteine and Vascular Diseases. Kluwer Academic Publishers; 2000;p. 16–34
  18. Brouwer IA, van Dusseldorp M, West CE, Meyboom S, Thomas CMG, Duran M, et al. Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. J Nutr. 1999;129:1135–1139
  19. Choen J. Statistical power analysis for the behavioural sciences. New York: Academic Press; 1977;
  20. Wise JA, Morin RJ, Sanderson R, Blum K. Changes in plasma carotenoid, alpha-tocopherol, and lipid peroxide levels in response to supplementation with concentrated fruit and vegetable extracts (a pilot study). Curr Ther Research. 1996;57:3–19
  21. McNeely MDD. Folic Acid assay. In:  Kaplan LA,  Pesce AJ editor. Clinical Chemistry. St. Louis: CV Mosby; 1984;p. 1402–1406
  22. McNamara JR, Leary ET, Ceriotti F, Boersma-Cobbaert CM, Cole TG, Hassemer DJ, et al.  Point (status of lipid and lipoprotein standardization). Clin Chem. 1997;43:1306–1310
  23. Candito M, Causse E, Couderc R, Demuth K, Drai J, Gachon AM, et al. Determination of total plasma homocysteine (preanalytical parameters, method comparison and interchangeability). Ann Biol Clin. 2002;60:317–319
  24. Brouwer IA, van Dusseldorp M, Thomas CMG, Duran M, Hautvast JGAJ, Eskes TKAB, et al. Low-dose folic acid supplementation decreases plasma homocysteine (A randomised trial). Am J Clin Nutr. 1999;69:99–104
  25. Jacob RA, Wu M-M, Henning SM, Swenseid ME. Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction. J Nutr. 1984;124:1072–1080
  26. O'Keef CA, Bailey LB, Thomas EA, Hofler SA, Davis BA, Cerda JJ, et al. III Controlled dietary folate affects folate status in nonpregnant women. J Nutr. 1995;125:2717–2725
  27. Ward M, McNulty H, McPartlin J, Strain JJ, Weir DG, Scott JM. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. Q J Med. 1997;90:519–524
  28. Smith MJ, Inserra PF, Watson RR, Wise JA, O'Neil KL. Supplementation with fruit and vegetables extracts may decrease DNA damage in the peripheral lymphocytes of an elderly population. Nutr Res. 1999;19:1507–1518
  29. Peterson JC, Spence DJ. Vitamins and progression of atherosclerosis in hyper-homocysteinemia. Lancet. 1998;351:263–265

PII: S0271-5317(03)00133-7

doi: 10.1016/S0271-5317(03)00133-7

Nutrition Research
Volume 23, Issue 9 , Pages 1221-1228 , September 2003

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