Nutrition Research
Volume 23, Issue 10 , Pages 1349-1353, October 2003

Intraoperative alteration of the total clearance of ascorbic acid in plasma

  • S Selhorst-Kiss

      Affiliations

    • Abteilung Anästhesiologie I, Medizinische Hochschule Hannover, Konstanty-Gutschow Str. 8, D-30625 Hannover, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-(0)6131-172793; fax: +49-(0)6131-175538.
    • ,
  • A Rümelin

      Affiliations

    • Klinik für Anästhesiologie, Johannes Gutenberg Universität Mainz Klinikum, Langenbeckstrasse 1, D-55131 Mainz, Germany
    • ,
  • I Ernst

      Affiliations

    • Abteilung Anästhesiologie I, Medizinische Hochschule Hannover, Konstanty-Gutschow Str. 8, D-30625 Hannover, Germany
    • ,
  • U Fauth

      Affiliations

    • Klinik für Anästhesiologie, Johannes Gutenberg Universität Mainz Klinikum, Langenbeckstrasse 1, D-55131 Mainz, Germany

Received 19 December 2002; received in revised form 24 June 2003; accepted 26 June 2003.

Abstract 

Ascorbic acid (AA) is an important antioxidant in the plasma and has the tendency to postoperatively reduced values. This could be caused by an increased antioxidative activity of AA as a radical scavenger since operations are a well-known scenario of oxidative stress with increased radical production. There is some evidence for an intraoperative onset of oxidative stress which could be related to an increased antioxidative activity of AA. Therefore, the total clearance (Cltot) of AA was calculated pre- and intraoperatively in 20 neurosurgical patients. At both times plasma samples were taken before, and 15, 30, 60 and 120 minutes after an iv. AA-bolus of 4 mg/kg AA/body weight.

Cltot of AA in plasma was significantly elevated (p < .005) intraoperatively. This result shows an significant increase in AA activity.

Keywords:  Ascorbic acid, Plasma, Operation, Antioxidant, Intraoperative clearance

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PII: S0271-5317(03)00150-7

doi:10.1016/S0271-5317(03)00150-7

Nutrition Research
Volume 23, Issue 10 , Pages 1349-1353, October 2003

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