Nutrition Research
Volume 23, Issue 10 , Pages 1369-1378 , October 2003

Association of apo E polymorphism with variations in lipid and small dense LDL in koreans with alow fat intake

  • Min-Jeong Shin

      Affiliations

    • Yonsei Cardiovascular Research Institute, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • ,
  • Eun Young Cho,

      Affiliations

    • Yonsei Cardiovascular Research Institute, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Cardiovascular Genome Center, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • ,
  • Hyun-Young Park

      Affiliations

    • Yonsei Cardiovascular Research Institute, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Cardiovascular Genome Center, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Yonsei University Research Institute of Science for Aging, Yonsei UniversityCollege of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • ,
  • Hong Keun Cho

      Affiliations

    • Yonsei Cardiovascular Research Institute, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Yonsei University Research Institute of Science for Aging, Yonsei UniversityCollege of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • ,
  • Jong Ho Lee

      Affiliations

    • Yonsei Cardiovascular Research Institute, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Cardiovascular Genome Center, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Yonsei University Research Institute of Science for Aging, Yonsei UniversityCollege of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • ,
  • Yangsoo Jang

      Affiliations

    • Yonsei Cardiovascular Research Institute, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Cardiovascular Genome Center, Institute of Science for Aging, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Yonsei University Research Institute of Science for Aging, Yonsei UniversityCollege of Medicine, 134 Sinchon-dong, Seodaemun-Gu, Seoul 120-752, South Korea
    • Corresponding Author InformationCorresponding author: Tel.: +82-2-361-7266; fax: +82-2-365-1878

References 

  1. Gómez-Coronado D, Álvarez JJ, Entrala A, Olmos JM, Herrera E, Lasunción MA. Apolipoprotein E polymorphism in men and women from a Spanish population (allele frequencies and influence on plasma lipids and apolipoproteins). Atherosclerosis. 1999;147:167–176
  2. Stuyt PM, Brennikmeijer BJ, Demacker PN. Apolipoprotein E phenotypes, serum lipoproteins and apolipoproteins in angiographically assessed coronary heart disease. Scand J Clin Lab. 1991;51:425–435
  3. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988;8:1–21
  4. Siest G, Pillot T, Regis-Bailly A, Leininger-Muller B, Steinmetz J, Galteau M-M, et al. Apolipopotein E (an important gene and protein to follow in laboratory medicine). Clin Chem. 1995;41:1068–1086
  5. Kesaniemi YA, Ehnholm C, Miettinen TA. Intestinal cholesterol absorption efficiency in man is related to apolipoprotein E phenotype. J Clin Invest. 1987;80:578–581
  6. Demant T, Bedford D, Packard CJ, Shepherd J. Influence of Apolipoprotein E polymorphism on Apolipoprotein B-100 metabolism in normolipidemic subjects. J Clin Invest. 1991;88:1490–1501
  7. Miettinen TA, Gylling H, Vanhanen H, Ollus A. Cholesterol absorption, elimination, and synthesis related to LDL kinetics during varing fat intake in men with different apolipoprotein E phenotypes. Arteriosclerosis Thromb Vasc Biol. 1992;12:1044–1052
  8. Nikkila M, Pitkajarvi T, Koivula T, Solakivi T, Lehtimaki T, Laippala P, et al. Women have a larger and less atherogenic low density lipoprotein particle size than men. Atherosclerosis. 1996;119:181–190
  9. Schaefer EJ, Lamon-Fava S, Johnson S, Ordovas JM, Schaefer MM, Castelli WP, et al. Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. Arteriosclerosis Thromb Vasc Biol. 1994;14:1105–1113
  10. Okumura K, Matsui H, Kawakami K, Numaguchi Y, Kaneko S, Morishima I, et al. Relationship between the apolipoprotein E and angiotensin-converting enzyme genotypes and LDL particle size in Japanese subjects. Clinica Chimica Acta. 1999;285:91–103
  11. Haffner SM, Stern MP, Miettinen H, Robbins D, Howard BV. Apolipoprotein E Polymorphism and LDL Size in a Biethnic Population. Arteriosclerosis Thromb Vasc Biol. 1996;16:1184–1188
  12. Valdez R, Howard BV, Stern MP, Haffner SM. Apolipoprotein E polymorphism and insulin levels in a biethnic population. Diabetes Care. 1995;18:992–1000
  13. Dembiska-Kie A, Kawecka-Jaszcz K, Kwaniak M, Guevara I, Pankiewicz J, Malczewska-Malec M, et al. Apo E isoforms, insulin output and plasma lipid levels in essential hypertension. European J Clin Invest. 1998;28:95–99
  14. Stiefel P, Montilla C, Muñiz-Grijalvo O, García-Lozano R, Alonso A, Miranda ML, et al. Apolipoprotein E gene polymorphism is related to metabolic abnormalities, but does not influence erythrocyte membrane lipid composition or sodium-lithium countertransport activity in essential hypertension. Metabolism. 2001;50:157–160
  15. Zhao SP, Verhoeven MH, Vink J, Hollaar L, van der Lassrse A, Knijff P, et al. Relationship between apolipoprotein E and low density lipoprotein particle size. Atherosclerosis. 1993;102:147–154
  16. Meigs JB, Ordovas JM, Cupples LA, Singer DE, Nathan DM, Schaefer EJ, et al. Apolipoprotein E isoform polymorphisms are not associated with insulin resistance (the Framingham Offspring Study). Diabetes Care. 2000;23:669–674
  17. Ordovas JM, Schaefer EJ. Genetic determinants of plasma lipid response to dietary intervention (the role of the APOA1/C3/A4 gene cluster and the APOE gene). Br J Nutr. 2000;83: S127–136
  18. Ordovas JM, Lopez MJ, Mata P. Gene-diet interaction in determining plasma lipid response of dietary intervention. Atherosclerosis. 1995;118:11–27
  19. Wilson PWF, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ. Apolipoprotein E alleles, dyslipidemia, and coronary heart disease (The Framingham Offspring Study). JAMA. 1994;272:1666–1671
  20. Boer JMA, Ehnholm C, Menzel HJ, Havekes LM, Rosseneu M, O'Reilly DS, et al. Interaction between lifestyle-related factors and the apo E polymorphism on plasma lipids and apolipoproteins. the EARS Study. Arteriosclerosis Thromb Vasc Biol. 1997;17:1675–1681
  21. Wilson PF, Schaefer E, Larson M, Ordovas JM. Apolipoprotein E alleles and risk of coronary disease. Arteriosclerosis Thromb Vasc Biol. 1996;16:1250–1255
  22. Kataoka S, Robbins DC, Cowan LD, Go O, Yeh JL, Devereux RB, et al. Apolipoprotein E polymorphism in American Indians and its relation to plasma lipoproteins and diabetes (the Strong Heart Study). Arteriosclerosis Thromb Vasc Biol. 1996;16:918–925
  23. Campos H, D'Agostino M, Ordovas JM. Gene-diet interactions and plasma ipoproteins (role of apolipoprotein E and habitual saturated fat intake). Genetic Epidemiology. 2001;20:117–128
  24. Aguilar CA, Talavera G, Ordovas JM, Barriguete JA, Guillen LE, Leco ME, et al. The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a Native American population following its traditional lifestyle. Atherosclerosis. 1999;142:409–414
  25. Stein AD, Shea S, Basch CE, Contento IR, Zybert P. Consistency of the Willett semi-quantitative food frequency questionnaire and 24-hour dietary recalls in estimating nutrient intakes of preschool children. Am J Epidemiol. 1992;135:667–677
  26. The Korean Nutrition Society, Republic of Korea. Recommended dietary allowances for Koreans. In: Seoul, Republic of Korea: The Korean Nutrition Society; 2000;p. 218–382
  27. Lipid Research Clinics Program. Manual of laboratory operations (lipid and lipoprotein analysis). In: US Dept Health: Education and Welfare publication; 2001;p. 75–628
  28. Griffin BA, Caslake MJ, Yip B, Tait GW, Packard CJ, Shepherd J. Rapid isolation of low density lipoprotein (LDL) subfractions from plasma by density gradient ultracentrifugation. Atherosclerosis. 1990;83:59–67
  29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biolog Chem. 1951;193:265–275
  30. Jang Y, Kim OY, Park HY, Lee JH, Ham JS, Ryu HJ. Effect of apolipoprotein E polymorphism on the serum lipid and insulin response to whole grain consumption in coronary artery disease patients. Nutr Res. 2001;21:1463–1473
  31. Castelii WP, Carrison RJ, Wilson PWF, Abbott RD, Kalousdian S, Kannel WB. Incidence of coronary heart disease and lipoprotein cholesterol levels (the Framingham Study). JAMA. 1986;256:2835–2838
  32. Djousse L, Myers RH, Coon H, Arnett DK, Province MA, Ellison RC. Smoking influences the association between apolipoprotein E and lipids (the National Heart, Lung, and Blood Institute Family Heart Study). Lipids. 2000;35:827–831
  33. Corella D, Tucker K, Lahoz C, Coltell O, Cupples LA, Wilson PW, et al. Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men (the Framingham Offspring Study). Am J Clin Nutr. 2001;73:736–745
  34. Loktionov A, Scollen S, McKeown N, Bingham SA. Gene-nutrient interactions (dietary behavior associated with high coronary heart disease risk particularly affects serum LDL cholesterol in apolipoprotein E ϵ4-carrying free-living individuals). Br J Nutr. 2000;84:885–890
  35. Corella D, Gullien M, Saiz C, Portoles O, Sabater A, Cortina S, et al. Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations (ecogenetic studies in a Mediterranean Spanish population). Metabolism. 2001;50:936–944
  36. Ordovas JM. The genetics of serum lipid responsiveness to dietary interventions. Proc Nutr Soc. 1999;58:171–187

PII: S0271-5317(03)00153-2

doi: 10.1016/S0271-5317(03)00153-2

Nutrition Research
Volume 23, Issue 10 , Pages 1369-1378 , October 2003

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