Nutrition Research
Volume 24, Issue 3 , Pages 197-207 , March 2004

Dietary nucleotides and intestinal cell lines: I. modulation of growth

  • Elisabeth Holen

      Affiliations

    • Broegelmann Research Laboratory, 5021 Armauer Hansen Building, N-5021 University of Bergen, N-5021 Bergen, Norway
    • National Institute of Nutrition and Seafood Research, Strandgaten 229, N-5804 Bergen, Norway
    • Corresponding Author InformationCorresponding author. Tel.: 47 55905134; Fax: 47 55905299.
    • ,
  • Roland Jonsson

      Affiliations

    • Broegelmann Research Laboratory, 5021 Armauer Hansen Building, N-5021 University of Bergen, N-5021 Bergen, Norway

Received 10 May 2003 ,Revised 5 November 2003 ,Accepted 11 November 2003.

References 

  1. Bronk JR, Hastewell JG. The transport of pyrimidines into tissue rings cut from rats mall intestine. J Physiol. 1998;382:475–478
  2. Carver JD, Walker WA. The role of nucleotides in human nutrition. Nutr Biochem. 1995;6:58–71
  3. Leleiko NS, Walsh MJ, Abraham S. Gene expression in the intestine; the effect of dietary nucleotides. In:  Barness LA,  DeVivo DC,  Kaback MM,  Morrow G,  Oski FA,  Rudolph A editor. Advances in paediatrics. St Louis: Mosby Yearbook; 1995;p. 145–169
  4. Arnaud A, Lopez-Pedrosa JM, Torres MI, Gil A. Dietary nucleotides modulate mitochondrial function of intestinal mucosa in weaning rats with chronic diarrhoea. J Paediatric Gastroenterol Nutr. 2003;37:124–131
  5. Ortega MA, Nunez MC, Gil A, SanchezPozo A. Dietary nucleotides accelerate intestinal recovery after food deprivation in old rats. J Nutr. 1995;125:1413–1418
  6. LopezNavarro AT, Ortega MA, Peragon J, Bueno JD, Gil A, SanchezPozo A. Deprivation of dietary nucleotides decreases protein synthesis in the liver and small intestine in rats. Gastroenterology. 1996;110:1760–1769
  7. Carver D. Dietary nucleotides (effects on the immune and gastrointestinal systems). Acta Paediatr. 1999;430(suppl):83–88
  8. Bueno JD, Torres M, Almendros A, Carmona R, Nunez MC, Rios A, et al. Effect of dietary nucleotides on small intestinal repair after diarrhoea. Histological and ultrastructural changes. Gut. 1994;35:926–933
  9. Brunser O, Espinoza J, Araya M, Cruchet S, Gil A. Effect of dietary nucleotide supplementation on diarrhoeal disease in infants. Acta Paediatr. 1994;83:188–191
  10. Uauy R, Quan R, Gil A. Role of nucleotides in intestinal development and repair (implications for infant nutrition). J Nutr. 1994;124(suppl):1436–1441
  11. Carver JD, Pimentel B, Cox WI, Barness LA. Dietary nucleotide effects upon immune function in infants. Paediatrics. 1991;88:359–363
  12. Martinez-Augustin O, Boza JJ, Del Pino JI, Lucena J, Martinez-Valverde A, Gil A. Dietary nucleotides might influence the humoral immune response against cow's milk proteins in preterm neonates. Biol Neonates. 1997;71:215–223
  13. Hamosh M. Should infant formulas be supplemented with bioactive components and conditionally essential nutrient present in human milk?. J Nutr. 1997;127(suppl):971–974
  14. Van der Hulst RR, von Meyenfeldt MF, van Kreel BK, Thunnissen FB, Brummer RJ, Arends JW, et al. Gut permeability, intestinal morphology and nutritional depletion. Nutrition. 1998;14:1
  15. Butzner D, Butler DG, Miniats P, Hamilton JT. Impact of chronic protein-calorie malnutrition on small intestinal repair after acute viral enteritis (a study in gnotobiotic piglets). Pediatr Res. 1995;19:476
  16. Buchman AL, Moukarzel AA, Bhuta S, Belle M, Ament ME, Eckhert CD, et al. Parental nutrition is associated with intestinal morphologic and functional changes in humans. J Pen Parenter Enter. 1995;19:453–460
  17. He Y, Chu SW, Walker WA. Nucleotide supplements alter proliferation and differentiation of cultured human CaCo-2 and rat (IEC-6) intestinal cells. J Nutr. 1993;123:1017–1027
  18. Darimont C, Gradoux N, Cumin F, Baum HP, De Pover A. Allowing the study of a polarised enterocyte monolayer in a commonly used model system. Exp Cell Res. 1998;244:441–447
  19. Chantret I, Barbat A, Dussaulx E, Brattain MG, Zweibaum A. Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells (a survey of twenty cell lines). Cancer Res. 1998;48:1936–1942
  20. Panigrahi P, Bamford P, Horwath K, Morris G, Gewolb IH. Escherichia coli transcytosis in a CaCo-2 cell model (implications in neonatal necrotizing enterocolitits). Pediatr Res. 1996;40:415–421
  21. Gil A, Uauy R. Nucleotides and related compounds in human and bovine milks. In:  Gordon JR editors. Handbook of milk composition. San Diego: Academic Press; 1995;p. 436–464
  22. Uauy R. Dietary nucleotides and requirements in early life. In:  Lebenthal E editors. Textbook of Gastroenterology and nutrition in infancy. New York: Raven Press; 1998;p. 265–280
  23. Kondo M, Yamaoka T, Honda S, Miwa Y, Katashima R, Moritani M, et al. The rate of cell growth is regulated by purine biosynthesis via ATP production and G1 to Sphase transition. J Biochem. 2000;128:57–64
  24. McCauley R, Kong SE, Hall J. Glutamine and nucleotide metabolism within enterocytes. J Parenteral Enteral Nutr. 1998;22:105–111
  25. Andersson IA, Youping HE. Nucleotide uptake and metabolism by intestinal epithelial cells. J Nutr. 1994;124:S131–S137
  26. Weber G. Biochemical strategy of cancer cells and the design of chemotherapy (GHA Clowes Memorial Lecture). Cancer Res. 1983;43:3466–3492
  27. Schlimme E, Martin D, Meisel H. Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. B J Nutr. 2000;84:S59–S68
  28. Owusu-Amoako M. Nutritional status and humoral immune response in Ghanian children. Master thesis, 2001, University of Bergen, Norway
  29. Yau K-IT, Huang C-B, Chen W, Chen S-j, Chou Y-H, Huang F-Y, et al. Effect of nucleotides on diarrhoea and immune response in healthy term infants in Taiwan. J Pediatr Gastr Nutr. 2003;36:37–43
  30. Hoepfner M, Maaser K, Barthel B, von Lamp B, Hanski C, Riecken EO, et al. Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells (involvement of intracellular calcium and cyclic adenosine monophosphate). Int J Colorectal Dis. 2001;16:154–166
  31. Burnstock G, Kennedy C. Is there a basis for distinguishing two types of P2-purinoceptor?. Gen Pharmacol. 1995;16:433–440
  32. North RA, Barnard EA. Nucleotide receptors. Curr Opin Neurobiol. 1997;7:346–357
  33. Olsson RA, Pearson JD. Cardiovascular purinoceptors. Physiol Rev. 1990;70:761–845
  34. Ramkumar V, Pierson G, Stiles GL. Adenosine receptors: clinical implications and biochemical mechanisms. Prog Drug Res. 1988;32:195–247
  35. Rathbone MP, Middlemis PJ, Kim JK, Gysbers JW, DeForge SP, Smith RW, et al. Adenosine and its nucleotides stimulate proliferation of chick astrocytes and human astrocytoma cells. Neurosci Res. 1992;13:1–17
  36. Shimegi S. Mitogenic action of adenosine on osteoblast-like cells, MC3T3-E1. Calcif Tissue Int. 1998;62:418–425
  37. Mazurek S, Michel A, Eigenbrodt E. Effect of extracellular AMP on cell proliferation and metabolism of breast cancer cell lines with high and low glycolytic rates. J Biol Chem. 1997;27:4941–4952
  38. Dignass AU, Becker A, Spiegler S, Goebell H. Adenine nucleotides modulates epithelial wound healing in vitro. Eur J Clin Invest. 1998;28:554–561
  39. Tressler RL, Ramstack MB, White NR, Molitor BE, Chen NR, Alarcon P, et al. Determination of total potentially available nucleosides in human milk from Asian women. Nutrition. 2003;19:16–20
  40. Jana LM, Picciano MF. The nucleotide profile of human milk. Pediatr Res. 1982;16:659–662
  41. Boza J. Nucleotides in infant nutrition. Monatsschr Kinderheilkd. 1998;146:S39–S48
  42. Aggett P, Leach JL, Rueda R, MacLean WC. Innovation in infant formula development (a reassessment of ribonucleotides in 2002). Nutrition. 2003;19:375–384
  43. Jefferies C, O'Neill LAJ. Signal transduction pathway activated by Toll-like receptors. Mod Asp Immunobiol. 2002;2:169–175
  44. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al. A Toll-like receptor recognises bacterial DNA. Nature. 2000;408:740–745
  45. Alexopoulou L, Holt A, Medzhitov R, Flavell RA. Recognition of double stranded RNA and activation of NF-kappa by Toll-like receptor 3. Nature. 2001;413:732–738
  46. He Y, Sanderson IR, Walker WA. Uptake, transport and metabolism of exogenous nucleosides in intestinal epithelial cell cultures. J Nutr. 1994;124:1942–1949
  47. Berthold HK, Crain PF, Gouni I, Reeds PJ, Klein PD. Evidence for incorporation of intact dietary pyrimidine (but not purine) nucleosides into hepatic RNA. Proc Natl Acad Sci USA. 1995;92:10123–10127
  48. Boza JJ, Jahoor F, Reeds PJ. Ribonucleic acid nucleotides in maternal and foetal tissues derive almost exclusively from synthesis de novo in pregnant mice. J Nutr. 1996;126:1749–1758

PII: S0271-5317(03)00243-4

doi: 10.1016/j.nutres.2003.11.004

Nutrition Research
Volume 24, Issue 3 , Pages 197-207 , March 2004

Article Tools

* Image Usage & Resolution