Nutrition Research
Volume 24, Issue 3 , Pages 223-227 , March 2004

Increased retinol requirement in acute measles infection in children: an hypothesis on role of hypercortisolemia

  • Cyril O. Enwonwu

      Affiliations

    • Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 666 West Baltimore Street, Baltimore, Maryland 21201, USA
    • Department of Biomedical Sciences, School of Dentistry, University of Maryland, 666 West Baltimore Street, Baltimore, Maryland 21201, USA
    • Corresponding Author InformationCorresponding author. Tel.: (410) 706-7186; Fax: (301) 317-1117.
    • ,
  • Reshma S. Phillips

      Affiliations

    • Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 666 West Baltimore Street, Baltimore, Maryland 21201, USA

Received 5 May 2003 ,Revised 20 October 2003 ,Accepted 26 October 2003.

References 

  1. Gerster H. Vitamin A—functions, dietary requirements and safety in humans. Int J Vit Nutr Res. 1997;67:71–90
  2. Ross AC. Retinoid production and catabolism (role of diet in regulating retinol esterification and retinoic acid oxidation). J Nutr. 2003;133:291S–296S
  3. Thurnham DI, Singkamani R. The acute phase response and vitamin A status in malaria. Trans Roy Soc Trop Med Hyg. 1991;85:194–199
  4. Ross AC. Vitamin A supplementation as therapy –are the benefits disease specific?. Am J Clin Nutr. 1998;68:8–9
  5. West CE. Vitamin A and measles. Nutr Rev. 2000;58:S46–S54
  6. Beisel WR. Infection-induced depression of serum retinol—a component of the acute phase response or a consequence?. Am J Clin Nutr. 1998;68:993–994
  7. Rosales FJ, Ross AC. A low molar ratio of retinol binding protein to transthyretin indicates vitamin A deficiency during inflammation (studies in rats and a posteriori analysis of vitamin A–supplemented children with measles). J Nutr. 1998;128:1681–1687
  8. Expanded Programme on Immunization, World Health Organization Expanded Programme on Immunization. Programme for prevention of nutrition blindness. Joint WHO/UNICEF statement on vitamin A for measles. Wkly Epidemiol Rec 1987;62:133–140
  9. World Health Organization. Expanded programme on Immunization. Report 1993. Geneva: World Health Organization, 1993:70
  10. Janeway CA, Moll GH, Armstrong SH, Wallace WM, Hallman N, Barness LA. Diuresis in children with nephrosis (comparison of response to injection of normal human albumin and to infection, particularly measles). Trans Assoc Am Phys. 1948;108:108–111
  11. Blumberg RW, Cassady HA. Effects of measles on the nephrotic syndrome. Am J Dis Child. 1947;63:151–156
  12. Anstead GM. Steroids, retinoids and wound healing. Adv Wound Care. 1998;11:227–285
  13. Sapse AT. Cortisol, high cortisol diseases and anti-cortisol therapy. Psychoneuroendocrinol. 1997;22(Suppl 1):S3–S10
  14. Atabani SF, Byrnes AA, Jaye A, et al.  Natural measles causes prolonged suppression of interleukin-12 production. J Infect Dis. 2001;184:1–9
  15. Okada H, Kobune F, Sato TA, Kohama T, Takeuchi Y, Abe T, et al. Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients. Arch Virol. 2000;145:905–920
  16. Naniche D, Oldstone MBA. Generalized immunosuppression (how viruses undermine the immune response). Cell Mol Life Sci. 2000;57:1399–1407
  17. Barnes PJ. Anti-inflammatory actions of glucocorticoids (molecular mechanisms). Clin Sci. 1998;94:557–572
  18. Munck A, Naray-Fejes-Toth A. The ups and downs of glucocorticoid physiology. Permissive and suppressive effects revisited. Mol Cell Endocrinol. 1992;90:C1–C4
  19. Wilckens T, De Rijk R. Glucocorticoids and immune functions (unknown dimensions and new frontiers). Immunol Today. 1997;18:418–424
  20. Clerici M, Trabattoni D, Piconi S, Fusi ML, Ruzzante S, Clerici C, et al. A possible role for the cortisol/anticortisols imbalance in the progression of human immunodeficiency virus. Psychoneuroendocrinol. 1997;22(Supplement 1):S27–31
  21. Wiegers J, Reul JMHM. Induction of cytokine receptors by glucocorticoids (functional and pathological significance). TiPS Trends in Pharmalogical Sciences. 1998;19:317–321
  22. Baumann H, Gauldie J. The acute phase response. Immunol Today. 1994;15:74–80
  23. Zeitoun MM, Hassan AI, Hussein ZM, Fahmy MS, Ragab M, Hussein M. Adrenal glucocorticoid function in acute viral infections in children. Acta Paediatr Scand. 1973;62:608–614
  24. Hassan AI, Zeitoun MM, Hussein ZM, Fahmy MS, Ragab M, Hussein M. Plasma 17-OHCS levels after vaccination against small pox and measles in children. Acta Paediatr Scand. 1972;61:577–580
  25. Enwonwu CO, Afolabi BM, Salako L, Idigbe EO, Al-Hassan H, Raibu RA. Hyperphenylalaninemia in African children with Falciparum malaria. Q J Med. 1999;92:495–503
  26. Rook GAW, Hernandez-Pando R. The pathogenesis of tuberculosis. Annu Rev Microbiol. 1996;50:259–284
  27. Atukorala TMS, Basu TK, Dickerson JWT. Effect of corticosterone on the plasma and tissue concentrations of vitamin A in rats. Ann Nutr Metab. 1981;25:234–238
  28. DeLuca LM, Kosa K, Andreola F. The role of vitamin A in differentiation and skin carcinogenesis. J Nutr Biochem. 1997;8:426–437
  29. Ingenbleek Y, Bernstein L. The stressful condition as a nutritionally dependent adaptive dichotomy. Nutrition. 1999;15:305–320

PII: S0271-5317(03)00251-3

doi: 10.1016/j.nutres.2003.10.004

Nutrition Research
Volume 24, Issue 3 , Pages 223-227 , March 2004

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