Nutrition Research
Volume 24, Issue 11 , Pages 935-944 , November 2004

Suppressive effects of dietary D-penicillamine on the gene expression of hepatic metallothionein-1 and protein level of hepatic metallothionein in Long-Evans Cinnamon rats

  • Hong Xu

      Affiliations

    • Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-Ku, Sapporo 060-8589, Japan
  • ,
  • Aki Nakagawa

      Affiliations

    • Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-Ku, Sapporo 060-8589, Japan
  • ,
  • Yoritaka Aoyama

      Affiliations

    • School of Health and Human Life, Nagoya Bunri University, 365 Maeda, Inazawa-cho, Inazawa, Aichi 492-8520, Japan
    • Corresponding Author InformationCorresponding author. Tel: +81-587-23-2400, Fax: +81-587-21-2844.

Received 14 July 2003 ,Revised 29 January 2004

References 

  1. Cousins RJ. Absorption, transport, and hepatic metabolism of copper and zinc (special reference to metallothionein and ceruloplasmin). Physiol Rev. 1985;65:236–309
  2. Dunn MA, Blalock TL, Cousins RJ. Metallothionein. Proc Soc Exp Biol Med. 1987;185:107–119
  3. Aoyama Y, Kato C. Suppressive effect of excess dietary histidine on the expression of hepatic metallothionein-1 in rats. Biosci Biotechnol Biochem. 2000;64:588–591
  4. Aoyama Y, Kato C, Sakakibara S. Expression of metallothionein in the liver and kidney of rats is influenced by excess dietary histidine. Comp Biochem Physiol. 2001;128C:339–347
  5. Kaewprasert S, Okada M, Aoyama Y. Metallothionein mRNA levels are influenced by dietary cyclodextrins in rats. J Nutr Biochem. 2002;13:219–225
  6. Blalock TL, Dunn MA, Cousins RJ. Metallothionein gene expression in rats (tissue-specific regulation by dietary copper and zinc). J Nutr. 1988;118:222–228
  7. Cousins RJ, Lee-Ambrose LM. Nuclear zinc uptake and interactions and metallothionein gene expression are influenced by dietary zinc. J Nutr. 1992;122:56–64
  8. Cui L, Takagi Y, Wasa M, Iiboshi Y, Inoue M, Khan J, et al. Zinc deficiency enhances interleukin-1–induced metallothionein-1 expression in rats. J Nutr. 1998;128:1092–1098
  9. Wu J, Forbes JR, Chen HS, Cox DW. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nature Genet. 1994;7:541–545
  10. Li Y, Togashi Y, Sato S, Emoto T, Kang J-H, Takeichi N, et al. Spontaneous hepatic copper accumulation in LEC rats with hereditary hepatitis (a model of Wilson's disease). J Clin Invest. 1991;87:1858–1861
  11. Muramatsu Y, Yamada T, Miura M, Sasaki T, Suzuki Y, Serikawa T, et al. Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans Cinnamon rats. Gastroenterology. 1994;107:1189–1192
  12. Masuda R, Yoshida M, Sasaki M. High susceptibility to hepatocellular carcinoma development in LEC rats with hepatitis. Jpn J Cancer Res. 1988;79:828–835
  13. Sone S, Maeda M, Gotoh M, Wakabayashi K, Ono T, Yoshida MC, et al. Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats. Mol Carcinog. 1992;5:199–204
  14. Mori M, Hattori A, Sawaki M, Tsuzuki N, Sawada N, Oyamada M, et al. The LEC rat (a model for human hepatitis, liver cancer, and much more). Am J Pathol. 1994;144:200–204
  15. Xu H, Sakakibara S, Morifuji M, Salamatulla Q, Aoyama Y. Excess dietary histidine decreases the liver copper level and serum alanine aminotransferase activity in Long-Evans Cinnamon rats. Br J Nutr. 2003;90:573–579
  16. Walshe JM. Penicillamine, a new oral therapy for Wilson's disease. Am J Med. 1956;21:587–595
  17. Scheinberg IH, Sternlieb I, Schilsky M, Stockert RJ. Penicillamine may detoxify copper in Wilson's disease. Lancet. 1987;ii:95
  18. Sternlieb I. Perspectives on Wilson's disease. Hepatology. 1990;12:1234–1239
  19. Togashi Y, Li Y, Kang JH, Takeichi N, Fujioka Y, Nagashima K, et al. D-penicillamine prevents the development of hepatitis in Long-Evans Cinnamon rats with abnormal copper metabolism. Hepatology. 1992;15:82–87
  20. Goering PL, Tandon K, Klaassen CD. Induction of hepatic metallothionein in mouse liver following administration of chelating agents. Toxicol Appl Pharmacol. 1985;80:467–472
  21. Heilmaier HE, Jiang JL, Greim H, Schramel P, Summer KH. D-penicillamine induces rat hepatic metallothionein. Toxicology. 1986;42:23–31
  22. Reeves PH, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents (final report of the American Institute of Nutrition ad hoc writing committee in the reformulation of the AIN-76A rodent diet). J Nutr. 1993;123:1939–1951
  23. Forbes RM, Erdman JW, Parker HM, Kondo H, Keleson SM. Bioavailability of zinc in coagulated soy protein (tofu) to rats and effect of dietary calcium at a constant phytate (zinc ratio). J Nutr. 1983;113:205–210
  24. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156–159
  25. Thomas PS. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci USA. 1980;77:5201–5205
  26. Onosaka S, Tanaka K, Doi M, Okahara K. A simplified procedure for determination of metallothionein in animal tissues. Eisei Kagaku. 1978;24:128–133
  27. Ohshita M, Takeda H, Kamiyama Y, Ozawa K, Honjo I. A direct method for the estimation of ornithine carbamoyltransferase activity in serum. Clin Chim Acta. 1976;67:145–152
  28. SnedecorGW, Cochran WG. Two-way classification, In: Statistical methods, 8thed. Ames, IA: Iowa State University Press, 1989. p.254–72
  29. Duncan DB. Multiple range and multiple F tests. Biometrics. 1955;11:1–42
  30. Sugawara N, Sugawara C, Katakura M, Takahashi H, Mori M. Copper metabolism in the LEC rats (involvement of induction of metallothionein and disposition of zinc and iron). Experientia. 1991;47:1060–1063
  31. Sawaki M, Enomoto K, Hattori A, Tsuzuki N, Sugawara N, Mori M. Role of copper accumulation and metallothionein induction in spontaneous liver cancer development in LEC rats. Carcinogenesis. 1994;15:1833–1837
  32. Nomiyama K, Nomiyama H. Critical concentration of “unbound” cadmium in the rabbit renal cortex. Experientia. 1982;42:149
  33. Suzuki KT. Induction and degradation of metallothionein and their relation to the toxicity of cadmium. In:  Foulkes EC editors. Biological roles of metallothionein. New York: Elsevier/North-Holland; 1982;p. 215–216

PII: S0271-5317(04)00067-3

doi: 10.1016/j.nutres.2004.04.007

Nutrition Research
Volume 24, Issue 11 , Pages 935-944 , November 2004