Nutrition Research
Volume 25, Issue 1 , Pages 79-92 , January 2005

Copper-iron metabolism interaction in rats

  • Lucía Ramírez-Cárdenas, MSc

      Affiliations

    • Department of Food Science and Technology, Federal University of Viçosa, MG 36570-00, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 31 3899 1268; fax: +55 31 3899 2541.
    • ,
  • Neuza Maria Brunoro Costa, PhD

      Affiliations

    • Department of Nutrition and Health, Federal University of Viçosa, MG 36570-00, Brazil
    • ,
  • Fernando Pinheiro Reis, MSc

      Affiliations

    • Department of Computer Science, Federal University of Viçosa, MG 36570-00, Brazil

Received 23 July 2003 ,Revised 7 October 2003 ,Accepted 9 July 2004.

References 

  1. Harris EC. Handbook of nutritionally essential mineral elements. In:  O'dell BL,  Sunde R editor. Marcel Dekker; 1997;p. 231–273
  2. Hart E, Steenbock H, Waddell J, Elvehjem C. Iron in nutrition. VII. Copper as a supplement to iron for hemoglobin building in the rat. J. Biol. Chem. 1928;77:797–812
  3. Williams D, Loukopoulos D, Lee G, Cartwright G. Role of copper in mitochondrial iron metabolism. Blood. 1976;48:77–85
  4. Smith S, Medlicott M. The blood picture of iron and copper deficiency anemias in the rat. Am. J. Physiol. 1944;141:354–358
  5. Lahey M, Gubler C, Chase M, Cartwright G, Wintrobe M. Studies on copper metabolism. Hematologic manifestations of copper deficiency in swine. Blood. 1952;7:1053–1074
  6. Saari J, Bode A, Dahlen G. Defects of copper deficiency in rats are modified by dietary treatments that affect glycation. J. Nutr. 1995;125:2925–2934
  7. Gubler C, Lahey M, Chase M, Cartwright G, Wintrobe M. Studies on copper metabolism. The metabolism of iron in copper deficient swine. Blood. 1952;7:1075–1092
  8. Dichi J, Burini RC. Metabolismo do Cobre e Anemia. Rev. Bras. Nutr. Clin. 1991;6:13–21
  9. Harris ED. The iron-copper connection: the link to ceruloplasmin grows stronger. Nutr. Rev. 1995;53:170–173
  10. Brody T. In: Nutritional biochemistry. California: Academic Press; 1994;p. 658
  11. Pedrosa L, Cozzolino S. Alterações metabólicas e funcionais do cobre em diabetes mellitus. In: Rev. Nutr. 12:1999;p. 213–224
  12. Fleet J. Zinc, copper and manganese. In:  Stipanuk MH editors. Biochemical and physiological aspects of human nutrition. Philadelphia: Saunders Company; 2000;p. 255–257
  13. Miyajima H, Takahashi Y, Serizawa M, Kaneko E, Gritlin J. Increased plasma lipid peroxidation in patients with aceruloplasminemia. F. R. Biol. Med. 1996;20:757–760
  14. Harris Z, Klomp L, Gitlin J. Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. Am. J. Clin. Nut. 1998;67(Suppl. S):972S–977S
  15. Yazaki M, Yoshida K, Nakamura A, Furihata K, Yonekawa M, Okabe T, et al. A novel splicing mutation in the ceruloplasmin gene responsible for hereditary ceruloplasmin deficiency with hemosiderosis. J. Neurol. Sci. 1998;156:30–34
  16. Harris ZL, Durley AP, Man TK, Gitlin JD. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc. Natl. Acad. Sci. U. S. A. 1999;96:10812–10817
  17. Conrad M, Umbreit J. Iron absorption and transport an update. Am. J. Hem. 2000;64:287–298
  18. Eisenstein R. Discovery of the ceruloplasmin homologue hephaestin: new insight into the copper/iron connection. Nutr. Rev. 2000;58:22–26
  19. Sakakibara S, Aoyama Y. Dietary iron-deficiency up-regulates hephaestin mRNA level in small intestine of rats. Life Sci. 2002;70:3123–3129
  20. O'dell BC. In: Organizacion Panamericana De La Salud, Organizacion Mundial De La Salud. Conocimientos actuales sobre nutrición. Sexta edición. ILSI Press; 1991;p. 301–308
  21. Saari J. Copper deficiency and cardiovascular disease: role of peroxidation, glycation and nitration. Can. J. Physiol. Pharmacol. 2000;78:848–855
  22. Corbett J, Mikhael A, Shimizu J, Frederick K, Misko T, Mcdaniel M, et al. Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc. Natl. Acad. Sci. U. S. A. 1993;90:8992–8995
  23. Fields M, Ferreti R, Smith C, Reiser S. The interaction of type of dietary carbohydrates with copper deficiency. Am. J. Clin. Nut. 1984;39:289–294
  24. Reeves P, Nielsen F, Fahey G. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76 A rodent diet. J. Nutr. 1993;123:1939–1951
  25. Association of Official Analytical Chemists—AOAC. In: Official methods of analysis of the Association of Official Analytical Chemists. 14th ed.. 1984;p. 880–881Washington, DC
  26. Nelson D, Morris M. Exame básico do sangue. In:  Henry JB editors. Diagnósticos clínicos and tratamento. Por métodos laboratoriais. Primeira edição brasileira. São Paulo: Editora Manole Ltda; 1995;p. 641–699
  27. Woo J, Cannon D. Intermediários metabólicos e íons inorgânicos. In:  Henry JB editors. Diagnósticos clínicos and tratamento. Por métodos laboratoriais. Primeira edição brasileira. São Paulo: Editora Manole Ltda; 1995;p. 159–195
  28. De Angelis RC, Mauron J, Finot PA, et al. Bioavailability of mineral elements in the Brazilian basic food system of rice and beans. Nutr. Res. 1985;5:969–981
  29. Hurrell RF. Bioavailability of iron. Eur. J. Clin. Nutr. 1997;51:S4–S8
  30. Martínez C, Ros G, Periago M, López G. Biodisponibilidad del hierro de los alimentos. Arch. Lat. Nutr. 1999;49:106–113
  31. Lee GR, Nacht S, Lukens J, Cartwright G. Iron metabolism in copper-deficient swine. J. Clin. Inv. 1968;47:2058–2069
  32. Young SP, Fahmy M, Golding S. Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells. FEBS Lett. 1997;411:93–96
  33. Osaki S, Johson DA, Frieden E. The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J. Biol. Chem. 1966;241:2746–2751
  34. Attieh ZK, Mukhopadhyay CK, Seshadri V, Tripoulas N, Fox PL. Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation–specific transport mechanism. J. Biol. Chem. 1999;274:1116–1123
  35. Evans J, Abraham P. Anemia, iron storage and ceruloplasmin in copper nutrition in the growing rat. J. Nutr. 1973;103:196–201
  36. Osaki S, Johnson DA, Frieden E. The mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxidase I. J. Biol. Chem. 1971;246:3018–3023
  37. Wood R, Han O. Recently identified molecular aspects of intestinal iron absorption. J. Nutr. 1998;128:1841–1844
  38. Harris ZL, Takahashi Y, Miyajima H, Serizawa M. Aceruloplasminemia: molecular characterization of this disorder of iron metabolism. Proc. Natl. Acad. Sci. U. S. A. 1995;92:2539–2543
  39. Mukhopadhyay CK, Attieh ZK, Fox PL. Role of ceruloplasmin in cellular iron uptake. Science. 1998;279:714–717
  40. Chase MS, Gubler C, Cartwright G, Wintrobe M. Studies on copper metabolism. IV. The influence of copper on the absorption of iron. J. Biol. Chem. 1952;199:757–763
  41. Hedges JD, Kornegay ET. Interrelationship of dietary copper and iron as measured by blood parameters, tissue stores and feedlot performance of swine. J. Anim. Sci. 1973;37:1147–1154
  42. Fairbanks VF. Iron in medicine and nutrition. In:  Shills ME,  Olson JA,  Shike M editor. Modern nutrition in health and disease. 8th ed.. Philadelphia: Lea & Febiger; 1994;p. 185–213
  43. Prohaska J. Biochemical changes in copper deficiency. J. Nutr. Biochem. 1990;1:452–461
  44. Bode AM, Miller LA, Faber J, Saari JT. Mitochondrial respiration in heart, liver, and kidney of copper-deficient rats. J. Nutr. Biochem. 1992;3:668–671
  45. Guyton A. Tratado de fisiología médica. In: Cuarta edición. México: Interamericana; 1971;p. 113
  46. Fritz J, Pla G, Harrison B, Clark G, Smith E. Measurement of the bioavailability of iron, using the rat hemoglobin repletion test. J. Assoc. Off. Anal. Chem. 1978;61:709–714
  47. Reiser S, Ferreti R, Fields M, Smith J. Role of dietary fructose in the enhancement of mortality and biochemical changes associated with copper deficiency in rats. Am. J. Clin. Nutr. 1983;38:214–222
  48. Fields M, Ferreti R, Smith C, Reiser S. Impairment of glucose tolerance in copper-deficient rats: dependency on the type of dietary carbohydrate. J. Nutr. 1984;114:393–397
  49. Saari J, Dahlen G. Early and advanced glycation end-products are increased in dietary copper deficiency. J. Nutr. Biochem. 1999;10:210–214

PII: S0271-5317(04)00130-7

doi: 10.1016/j.nutres.2004.07.003

Nutrition Research
Volume 25, Issue 1 , Pages 79-92 , January 2005

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