Nutrition Research
Volume 24, Issue 11 , Pages 901-908 , November 2004

Effects of fiber and fat on murine proximal colonic mucosal proliferation and crypt depth

  • Marc D. Basson

      Affiliations

    • Department of Surgery, John D. Dingell Veterans Administration Medical Center and Wayne State University, Detroit, MI 48201-1932, USA
    • Corresponding Author InformationCorresponding author. Marc D. Basson, Chief of Surgical Services, John D. Dingell VA Medical Center, Detroit, MI 48201-1932, USA. Tel.: +1 313 576 3598; fax: +1 313 576 1002.
    • ,
  • Cheng Fang Yu

      Affiliations

    • Bristol-Myers Squibb, 5 Research Pkwy, Wallingford, CT 06492, USA
    • ,
  • Ruben Gomez

      Affiliations

    • Department of Surgery, John D. Dingell Veterans Administration Medical Center and Wayne State University, Detroit, MI 48201-1932, USA
    • ,
  • Omar Bashir

      Affiliations

    • Department of Cancer Research UK, Histopathology Unit, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
    • ,
  • Robert A. Goodlad

      Affiliations

    • Department of Cancer Research UK, Histopathology Unit, 44 Lincoln's Inn Fields, London WC2A 3PX, UK

Received 21 November 2003 ,Revised 24 June 2004 ,Accepted 28 June 2004.

References 

  1. Yu CF, Whiteley L, Carryl O, Basson MD. Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig. Dis. Sci. 2001;46:1367–1380
  2. Basson MD, Li GD, Hong F, Han O, Sumpio BE. Amplitude-dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco-2 monolayers. J. Cell. Physiol. 1996;168:476–488
  3. Murnin M, Kumar A, Li GD, Brown M, Sumpio BE, Basson MD. Effects of glutamine isomers on human (Caco-2) intestinal epithelial proliferation, strain-responsiveness, and differentiation. J. Gastrointest. Surg. 2000;4:435–442
  4. Han O, Li GD, Sumpio BE, Basson MD. Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals. Am. J. Physiol. 1998;275:G534–G541
  5. Li W, Duzgun A, Sumpio BE, Basson MD. Integrin and FAK-mediated MAPK activation is required for cyclic strain mitogenic effects in Caco-2 cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2001;280:G75–G87
  6. Zhang J, Li W, Sanders MA, Sumpio BE, Panja A, Basson MD. Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins. FASEB J. 2003;17:926–928
  7. Basson MD, Coppola CP. Repetitive deformation and pressure activate small bowel and colonic mucosal tyrosine kinase activity in vivo. Metab. Clin. Exp. 2002;51:1525–1527
  8. Murakami H, Iwane S, Munakata A, Nakaji S, Sugawara K, Tsuchida S, et al. Changes in intraluminal pressure in rat large intestines with aging and effects of dietary fiber. Dig. Dis. Sci. 2001;46:1247–1254
  9. Goodlad RA, Wright NA. The effect of starvation and refeeding on intestinal cell proliferation in the mouse. Virchows Arch., B Pathol. 1984;45:63–73
  10. Reddy BS. Dietary fat and colon cancer: animal model studies. Lipids. 1992;27:807–813
  11. Sesink AL, Termont DS, Kleibeuker JH, Van Der Meer R. Red meat and colon cancer: dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium. Carcinogenesis. 2000;21:1909–1915
  12. Bird RP, Medline A, Furrer R, Bruce WR. Toxicity of orally administered fat to the colonic epithelium of mice. Carcinogenesis. 1985;6:1063–1066
  13. Stadler J, Stern HS, Yeung KS, McGuire V, Furrer R, Marcon N, et al. Effect of high fat consumption on cell proliferation activity of colorectal mucosa and on soluble faecal bile acids. Gut. 1988;29:1326–1331
  14. Chapkin RS, Gao J, Lee DY, Lupton JR. Dietary fibers and fats alter rat colon protein kinase C activity: correlation to cell proliferation. J. Nutr. 1993;123:649–655
  15. Pajari AM, Oikarinen S, Grasten S, Mutanen M. Diets enriched with cereal brans or inulin modulate protein kinase C activity and isozyme expression in rat colonic mucosa. Br. J. Nutr. 2000;84:635–643
  16. Pell JD, Gee JM, Wortley GM, Johnson IT. Dietary corn oil and guar gum stimulate intestinal crypt cell proliferation in rats by independent but potentially synergistic mechanisms. J. Nutr. 1992;122:2447–2456
  17. Lee DY, Chapkin RS, Lupton JR. Dietary fat and fiber modulate colonic cell proliferation in an interactive site-specific manner. Nutr. Cancer. 1993;20:107–118
  18. Brunsgaard G. Effects of cereal type and feed particle size on morphological characteristics, epithelial cell proliferation, and lectin binding patterns in the large intestine of pigs. J. Anim. Sci. 1998;76:2787–2798
  19. Fuchs CS, Giovannucci EL, Colditz GA, Hunter DJ, Stampfer MJ, Rosner B, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N. Engl. J. Med. 1999;340:169–176
  20. Schatzkin A, Lanza E, Corle D, Lance P, Iber F, Caan B, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. N. Engl. J. Med. 2000;342:1149–1155
  21. Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T, et al. Dietary fibre in food and protection against colorectal cancer in European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet. 2003;361:1496–1501
  22. Peters U, Sinha R, Chatterjee N, Subar AF, Ziegler RG, Kulldorff M, et al. Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme. Lancet. 2003;361:1491–1495
  23. Brodribb AJ, Condon RE, Cowles V, DeCosse JJ. Effect of dietary fiber on intraluminal pressure and myoelectric activity of left colon in monkeys. Gastroenterology. 1979;77:70–74
  24. Basson MD, Coppola C. Repetitive deformation and pressure activate small bowel and colonic mucosal tyrosine kinase activity in vivo. Metabolism. 2002;51:1525–1527
  25. Basson MD. Paradigms for mechanical signal transduction in the intestinal epithelium. Digestion. 2003;68:217–225
  26. Thamilselvan VJ, Basson MD. Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. Gastroenterology. 2004;126:8–18

PII: S0271-5317(04)00133-2

doi: 10.1016/j.nutres.2004.06.009

Nutrition Research
Volume 24, Issue 11 , Pages 901-908 , November 2004

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