Nutrition Research
Volume 25, Issue 1 , Pages 55-63, January 2005

Effects of kefir containing various levels of fat on chemically induced colorectal epithelial tumors in Wistar rats

  • Cirila Hlastan-Ribič

      Affiliations

    • Department of Public Health, Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
    • Government of Slovenia, Ministry of Health, 1000 Ljubljana, Slovenia
    • Corresponding Author InformationCorresponding author. Department of Public Health, Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia. Tel.: +386 0 1 478 68 54; fax: +386 0 1 478 65 56.
    • ,
  • Anton Cerar

      Affiliations

    • Medical Experimental Centre, Institute of Pathology, Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
    • ,
  • Dražigost Pokorn

      Affiliations

    • Department of Public Health, Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
    • ,
  • Martina Perše

      Affiliations

    • Medical Experimental Centre, Institute of Pathology, Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
    • ,
  • Ana Zebič

      Affiliations

    • Veterinary Faculty, University of Ljubljana, SI-1115 Ljubljana, Slovenia

Received 31 March 2004; received in revised form 4 October 2004; accepted 22 October 2004.

Abstract 

Epidemiological investigations have suggested a relationship between the nutrition and the incidence of various types of cancer. The aim of the study was to determine the effect of kefir (with different fat levels) and milk on the incidence of experimentally induced colorectal epithelial tumors. We used 120 ten-week-old male Wistar rats. In addition to a standard feeding regimen, the first experimental group received kefir containing 3.5% fat. A second group received kefir with 1.1% fat, and a third group received sterilized milk with 1.1% fat. The kefir 3.5% fat group had the highest number of adenocarcinomas. The lowest number of adenocarcinomas was found in the group given 1.1% milk fat. We found a statistically high correlation between the incidence of adenocarcinomas and the fat intake (P = .0338), and a high statistical correlation between the incidence of all forms of colorectal epithelial tumors (aberrant crypt foci, adenomas, and adenocarcinomas) and the intake of fat (P < .001).

Keywords: Fermented milk, Kefir, Rats, Fat, Colorectal epithelial tumor

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PII: S0271-5317(04)00195-2

doi:10.1016/j.nutres.2004.10.002

Nutrition Research
Volume 25, Issue 1 , Pages 55-63, January 2005

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