Nutrition Research
Volume 25, Issue 5 , Pages 491-497 , May 2005

Dietary metformin effects on in vitro and in vivo metabolism in the chicken

Received 6 July 2004 ,Revised 17 February 2005 ,Accepted 1 March 2005.

References 

  1. Santure M, Pitre M, Gaudreault N, Marette A, Nadeau A, Bachelard H. Effect of metformin on the vascular and glucose metabolic actions of insulin in hypertensive rats. Am J Physiol. 2000;278:682–692
  2. McMurtry JP, Rosebrough RW, Steele NC. A homologous radioimmunoassay for chicken insulin. Poult Sci. 1983;62:697–701
  3. Ashwell CM, McMurtry JP. Hypoglycemia and reduced feed intake in broiler chickens treated with metformin. Poult Sci. 2003;82:106–110
  4. Kiersztan A, Modzelewska A, Jarzyna R, Jagielska E, Bryla J. Inhibition of gluconeogenesis by vanadium and metformin in kidney-cortex tubules isolated from control and diabetic rabbits. Biochem Pharmacol. 2002;63:1371–1382
  5. Yuan L, Ziegler R, Hamann A. Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes. Chin Med J (Engl). 2002;115:1843–1848
  6. Otto M, Breinholt J, Westergaard N. Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab. 2003;5:189–194
  7. Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: an update. Ann Intern Med. 2002;137:25–33
  8. Rosebrough RW, Steele NC. Methods to assess glucose and lipid metabolism in avian liver explants. Comp Biochem Physiol. 1988;88A:1041–1049
  9. Rosebrough RW, Steele NC. Dietary crude protein levels and the effect of isoproterenol on in vitro lipogenesis in the chicken. J Nutr. 1990;120:1684–1691
  10. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497–509
  11. Hsu RY, Lardy HA. Malic enzyme. In:  Lowenstein JM editors. Methods in Enzymology. vol. 63:New York: Academic Press; 1969;p. 1371–1382
  12. Cleland WW, Thompson VM, Barden RE. Isocitrate dehydrogenase (TPN specific) from pig heart. In:  Lowenstein JM editors. Methods in Enzymology. vol. 13:New York: Academic Press; 1969;p. 30–33
  13. Martin RJ, Herbein JH. A comparison of the enzyme levels and in vitro utilization of various substrates for lipogenesis in pair-fed lean and obese pigs. Proc Soc Exp Biol Med. 1976;151:231–235
  14. Chida Y, Ohtsu H, Takahashi K, Sato K, Toyomizu M, Akiba Y. Carbohydrate metabolism in temporal and persistent hypoglycemic chickens induced by insulin infusion. Comp Biochem Physiol. 2000;126:187–193
  15. Simon J, Derouet M, Gespach C. An anti-insulin serum, but not a glucagon antagonist, alters glycemia in fed chickens. Horm Metab Res. 2000;32:139–141
  16. Rosebrough RW, McMurtry JP. Insulin, glucagon and catecholamine interactions in avian liver explants. Comp Biochem Physiol. 1992;103B:281–287
  17. Landin K, Tengborn L, Smith U. Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factors. J Intern Med. 1991;229:181–187
  18. Giugliano D, Quatraro A, Consoli G, Minei A, Ceriello A, De Rosa N, et al. Metformin for obese, insulin-treated diabetic patients: improvement in glycaemic control and reduction of metabolic risk factors. Eur J Clin Pharmacol. 1983;44:107–112
  19. Giugliano D, De Rosa N, Di Maro G, Marfella R, Acampora R, Buoninconti R, et al. Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women. Diabetes Care. 1993;16:1387–1390

☆ Mention of a trade name, proprietary product, or vendor does not constitute a guarantee or warranty of the product by USDA or imply its approval to the exclusion of other suitable products or vendors.

PII: S0271-5317(05)00062-X

doi: 10.1016/j.nutres.2005.03.001

Nutrition Research
Volume 25, Issue 5 , Pages 491-497 , May 2005

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