Nutrition Research
Volume 27, Issue 12 , Pages 772-777 , December 2007

Tumor necrosis factor α attenuates glutamine-enhanced skeletal muscle protein synthesis in rats

  • Jihong Zhou

      Affiliations

    • Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China
  • ,
  • Yousheng Li

      Affiliations

    • Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 25 80860137; fax: +86 25 84803956.
  • ,
  • Fangnan Liu

      Affiliations

    • Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China
  • ,
  • Yacheng Cao

      Affiliations

    • Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210002, China
  • ,
  • Jieshou Li

      Affiliations

    • Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China

Received 16 March 2007 ,Revised 7 July 2007 ,Accepted 12 September 2007.

References 

  1. Garcia-de-Lorenzo A, Zarazaga A, Garcia-Luna PP, Gonzalez-Huix F, Lopez-Martinez J, Mijan A, et al. Clinical evidence for enteral nutritional support with glutamine: a systematic review. Nutrition. 2003;19:805–811
  2. Griffiths RD, Allen KD, Andrews FJ, Jones C. Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection. Nutrition. 2002;18:546–552
  3. Goeters C, Wenn A, Mertes N, Wempe C, Van Aken H, Stehle P, et al. Parenteral l-alanyl-l-glutamine improves 6-month outcome in critically ill patients. Crit Care Med. 2002;30:2032–2037
  4. Montejo JC. Enteral nutrition-related gastrointestinal complications in critically ill patients: a multicenter study. The Nutritional and Metabolic Working Group of the Spanish Society of Intensive Care Medicine and Coronary Units. Crit Care Med. 1999;27:1447–1453
  5. Heyland DK, Novak F, Drover JW, Jain M, Su X, Suchner U. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA. 2001;286:944–953
  6. Wilmore DW, Shabert JK. Role of glutamine in immunologic responses. Nutrition. 1998;14:618–626
  7. D'Souza R, Powell-Tuck J. Glutamine supplements in the critically ill. J R Soc Med. 2004;97:425–427
  8. Melis GC, ter Wengel N, Boelens PG, van Leeuwen PA. Glutamine: recent developments in research on the clinical significance of glutamine. Curr Opin Clin Nutr Metab Care. 2004;7:59–70
  9. Novak F, Heyland DK, Avenell A, Drover JW, Su X. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med. 2002;30:2022–2029
  10. Griffiths RD, Jones C, Palmer TE. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition. 1997;13:295–302
  11. Wischmeyer PE, Riehm J, Singleton KD, Ren H, Musch MW, Kahana M, et al. Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition. 2003;19:1–6
  12. Eizaguirre I, Aldazabal P, Barrena MJ, Garcia-Arenzana JM, Ariz C, Candelas S, et al. Effect of growth hormone on bacterial translocation in experimental short-bowel syndrome. Pediatr Surg Int. 1999;15:160–163
  13. Lang CH, Frost RA, Nairn AC, MacLean DA, Vary TC. TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation. Am J Physiol. 2002;282:E336–E347
  14. Liu F, Li J, Chen Y, Li Y. Plasma glutamine level monitored with high performance liquid chromatography for patient infusing glutamine after small bowel transplantation. Chinese Journal of Chromatography (Se Pu). 1997;15:445–447
  15. Garlick PJ, Wernerman J, McNurlan MA, Essen P, Lobley GE, Milne E, et al. Measurement of the rate of protein synthesis in muscle of postabsorptive young men by injection of a ‘flooding dose’ of [1-13C]leucine. Clin Sci. 1989;77:29–36
  16. O'Leary MJ, Ferguson CN, Rennie MJ, Hinds CJ, Coakley JH, Preedy VR. Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat. Clin Sci (Lond). 2001;101:295–304
  17. Zilversmit DB. The design and analysis of isotope experiments. Am J Med. 1960;29:832–848
  18. Oehler R, Roth E. Regulative capacity of glutamine. Curr Opin Clin Nutr Metab Care. 2003;6:277–282
  19. Yeh SL, Lai YN, Shang HF, Lin MT, Chen WJ. Effects of glutamine supplementation on innate immune response in rats with gut-derived sepsis. Br J Nutr. 2004;91:423–429
  20. Houdijk AP, Rijnsburger ER, Jansen J, Wesdorp RI, Weiss JK, McCamish MA, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet. 1998;352:772–776
  21. Wischmeyer PE, Lynch J, Liedel J, Wolfson R, Riehm J, Gottlieb L, et al. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. Crit Care Med. 2001;29:2075–2080
  22. Li Y, Li J, Jiang J, Li N, Wang X, Wang Z, et al. Glycyl-glutamine–supplemented long-term total parenteral nutrition selectively improves structure and function in heterotopic small-bowel autotransplantation in the pig. Transpl Int. 2003;16:866–871
  23. O'Leary MJ, Ferguson CN, Rennie M, Hinds CJ, Coakley JH, Preedy VR. Effect of growth hormone on muscle and liver protein synthesis in septic rats receiving glutamine-enriched parenteral nutrition. Crit Care Med. 2002;30:1099–1105
  24. Safranek R, Holecek M, Sispera L, Muthny T. Aspects of protein and amino acid metabolism in a model of severe glutamine deficiency in sepsis. Ann Nutr Metab. 2006;50:361–367
  25. Naka S, Saito H, Hashiguchi Y, Lin M, Furukawa S, Inaba T, et al. Alanyl-glutamine–supplemented total parenteral nutrition improves survival and protein metabolism in rat protracted bacterial peritonitis model. JPEN J Parenter Enteral Nutr. 1996;20:417–423
  26. Gore DC, Wolfe RR. Glutamine supplementation fails to affect muscle protein kinetics in critically ill patients. JPEN J Parenter Enteral Nutr. 2002;26:342–349
  27. Jepson MM, Millward DJ. Impact of glutamine infusions on muscle protein synthesis in fasted and endotoxin treated rats. Clin Nutr. 1991;10:43–46
  28. Olde Damink SW, de Blaauw I, Deutz NE, Soeters PB. Effects in vivo of decreased plasma and intracellular muscle glutamine concentration on whole-body and hindquarter protein kinetics in rats. Clin Sci (Lond). 1999;96:639–646
  29. Lundberg IE, Dastmalchi M. Possible pathogenic mechanisms in inflammatory myopathies. Rheum Dis Clin North Am. 2002;28:799–822
  30. Reid MB, Li YP. Cytokines and oxidative signalling in skeletal muscle. Acta Physiol Scand. 2001;171:225–232
  31. Fan J, Char D, Bagby GJ, Gelato MC, Lang CH. Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by tumor necrosis factor. Am J Physiol. 1995;269:R1204–R1212
  32. Chai J, Wu Y, Sheng ZZ. Role of ubiquitin-proteasome pathway in skeletal muscle wasting in rats with endotoxemia. Crit Care Med. 2003;31:1802–1807
  33. Alpers DH. Is glutamine a unique fuel for small intestinal cells?. Curr Opin Gastroenterol. 2000;16:155
  34. Mignon M, Leveque L, Bonnel E, Meynial-Denis D. Does concomitant glucose and glutamine supplementation change the response of glutamine synthetase to fasting in healthy adult rats?. Clin Nutr. 2007;26:662–666
  35. Van Way CW, Dhar A, Morrison DC, Longorio MA, Maxfield DM. Cellular energetics in hemorrhagic shock: restoring adenosine triphosphate to the cells. J Trauma. 2003;54:S169–S176
  36. Curi R, Lagranha CJ, Doi SQ, Sellitti DF, Procopio J, Pithon-Curi TC, et al. Molecular mechanisms of glutamine action. J Cell Physiol. 2005;204:392–401
  37. Liu Z, Jahn LA, Wei L, Long W, Barrett EJ. Amino acids stimulate translation initiation and protein synthesis through an Akt-independent pathway in human skeletal muscle. J Clin Endocrinol Metab. 2002;87:5553–5558
  38. Jefferson LS, Kimball SR. Amino acids as regulators of gene expression at the level of mRNA translation. J Nutr. 2003;133:2046S–2051S
  39. Liu Z, Wu Y, Nicklas EW, Jahn LA, Price WJ, Barrett EJ. Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle. Am J Physiol Endocrinol Metab. 2004;286:E523–E528
  40. Liu Z, Long W, Fryburg DA, Barrett EJ. The regulation of body and skeletal muscle protein metabolism by hormones and amino acids. J Nutr. 2006;136:212S–217S
  41. Kalhan SC, Edmison JM. Effect of intravenous amino acids on protein kinetics in preterm infants. Curr Opin Clin Nutr Metab Care. 2007;10:69–74
  42. Kimball SR, Jefferson LS. New functions for amino acids: effects on gene transcription and translation. Am J Clin Nutr. 2006;83:500S–507S
  43. Kimball SR, Orellana RA, O'Connor PM, Suryawan A, Bush JA, Nguyen HV, et al. Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs. Am J Physiol. 2003;285:E637–E644
  44. Vary TC, Kimball SR. Effect of sepsis on eIE4E availability in skeletal muscle. Am J Physiol. 2000;279:E1178–E1184
  45. Williamson DL, Kimball SR, Jefferson LS. Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. Am J Physiol. 2005;289:E95–E104

PII: S0271-5317(07)00222-9

doi: 10.1016/j.nutres.2007.09.010

Nutrition Research
Volume 27, Issue 12 , Pages 772-777 , December 2007