Nutrition Research
Volume 28, Issue 4 , Pages 278-284 , April 2008

Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced diabetic mice

  • Xiang-Yang Qi

      Affiliations

    • College of Biological Environmental Sciences, Zhejiang Wali College, Ningbo 315100, China
    • Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    • Corresponding Author InformationCorresponding author. College of Biological Environmental Sciences, Zhejiang Wali College, Ningbo, 315100, China. Tel.: +86 0574 87222662; fax: +86 0574 87222662.
    • ,
  • Wei-Jun Chen

      Affiliations

    • Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    • ,
  • Li-Qin Zhang

      Affiliations

    • Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    • ,
  • Bi-Jun Xie

      Affiliations

    • Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China

Received 19 June 2007 ,Revised 25 December 2007 ,Accepted 5 February 2008.

References 

  1. Valiathan MS. Healing plants. Curr Sci. 1998;75(11):1122–1126
  2. Kuyvenhoven JP, Meinders AE. Oxidative stress and diabetes mellitus. Pathogenesis of long term complications. Eur J Intern Med. 1999;10:9–19
  3. West IC. Radicals and oxidative stress in diabetes. Diabet Med. 2000;17:171–180
  4. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: global burden of disease study. Lancet. 1997;349:1269–1276
  5. Holman RR, Turner RC. Diabetes. In:  Pickup JC,  Williams G editor. Oral agents and insulin in the treatment of NIDDM. Oxford: Book of Blackwell; 1991;p. 467–469
  6. Pari L, Umamaheswari J. Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats. Phytother Res. 2000;14:1–3
  7. Kamei C, Sugiura M. New pharmacological functions of Luo Han Guo. J Jpn Foods & Food Ingred. 2005;210(3):244–254
  8. Ukiya M, Akihisa T, Tokuda H, Toriumi M, Mukainaka T, Banno N, et al. Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on Epstein-Barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate. J Agric Food Chem. 2002;50:6710–6715
  9. Ukiya M, Akihisa T, Yasukawa K, Tokuda H, Toriumi M, Koike K, et al. Anti-inflammatory and anti-tumor–promoting effects of cucurbitane glycosides from the roots of Bryonia dioica. J Nat Prod. 2002;65:179–183
  10. Suzuki YA, Murata Y, Inui H, Sugiura M, Nakano Y. Triterpene glycosides of Siraitia grosvenori inhibit rat intestinal maltase and suppress the rise in blood glucose level after a single oral administration of maltose in rats. J Agric Food Chem. 2005;53(8):2941–2946
  11. Takeo E, Yoshida H, Tada N, Shingu T, Matsuura H, Murata Y, et al. Sweet elements of Siraitia (Momordica) grosvenori inhibit oxidative modification of low density lipoprotein. J Atheroscler Thromb. 2002;9:114–120
  12. Takasaki M, Konoshima T, Murata Y, Sugiura M, Nishino H, Tokuda H, et al. Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori. Cancer Lett. 2003;198:37–42
  13. Godin DV, Wohaieb SA, Garnett ME, Goumeniouk AD. Antioxidant enzyme alterations in experimental and clinical diabetes. Mol Cell Biochem. 1988;84:223–231
  14. Szaleczky E, Prechl J, Feher J, Somogyi A. Alterations in enzymatic antioxidant defence in diabetes mellitus—a rational approach. Postgrad Med J. 1999;75:13–17
  15. Tong HB, Liang ZY, Wang GY. Structural characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Physalis alkekengi L. Carbohydr Polym. 2008;71:316–323
  16. Chen HX, Zhang M, Xie BJ. Components and antioxidant activity of polysaccharide conjugate from green tea. Food Chem. 2005;90:17–21
  17. Barham D, Trinder P. An improved color reagent for the determination of blood glucose by the oxidase system. Analyst. 1972;142–145
  18. Allain CC, Poon LS, Chen CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470–475
  19. Suttle NF. Copper deficiency in ruminants: recent developments. Vet Res. 1986;119(21):519–522
  20. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte GSH-Px. J Lab Clin Med. 1967;70(1):158–169
  21. Jain SK, Levine SN, Duett J, Hollier B. Elevated lipid peroxidation levels in red blood cells of streptozotocin-treated diabetic rats. Metabolism. 1990;39:971–975
  22. Halliwell B, John M, Okezie I. The deoxyribose method: a simple “test-tube” assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem. 1987;165:215–219
  23. Chang HJ, Se HM, Cho IW, Cho HD, Cho HY. Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats. J Ethnopharmacol. 2005;98:245–250
  24. Achyut NK, Shweta K, Santosh KS, Rajesh KG, Geeta W. Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals. J Ethnopharmacol. 2007;112:305–311
  25. Saravanan R, Pari L. Antihyperlipidemic and antiperoxidative effect of diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. BMC Complement Altern Med. 2005;5:1–10
  26. Fumelli P, Romagnoli F, Carlino G, Fumelli C, Boemi M. Diabetes mellitus and chronic heart failure. Arch Gerontol Geriatr. 1996;23:277–281
  27. Sharma SB, Nasir A, Prabhu KM, Murthy PS, Gev G. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol. 2003;85:201–206
  28. Bonnefont Rousselot D, Bastard JP, Jaudon MC, Delattre J. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes Metab. 2000;26:163–176
  29. Sindhu RK, Koo JR, Roberts CK, Vaziri ND. Dysregulation of hepatic SOD, CAT and GSH-Px in diabetes: response to insulin and antioxidant therapy. Clin Exp Hypertens. 2004;26(1):43–53
  30. El-Missiry MA, El-Gindy AM. Amelioration of alloxan induced diabetes mellitus and oxidative stress in rats by oil Eruca sativa seeds. Ann Nutr Metab. 2000;44:97–100
  31. Zigler JS, Hess HH. Evidence of initiation by lipid peroxidation products. Exp Eye Res. 1985;41:67–76
  32. Irshad M, Chaudhuri PS. Oxidant-antioxidant system: role and significance in human body. Indian J Exp Biol. 2002;40:1233–1239
  33. Vendemiale G, Grattagliano I, Altomare E. An update on the role of free radicals and antioxidant defense in human disease. Int J Clin Lab Res. 1999;29(2):49–55

PII: S0271-5317(08)00036-5

doi: 10.1016/j.nutres.2008.02.008

Nutrition Research
Volume 28, Issue 4 , Pages 278-284 , April 2008

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