Nutrition Research
Volume 28, Issue 12 , Pages 816-824 , December 2008

Lower estimates of δ-5 desaturase and elongase activity are related to adverse profiles for several metabolic risk factors in young Japanese women

  • Kentaro Murakami

      Affiliations

    • Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo 113-0033, Japan
    • ,
  • Satoshi Sasaki

      Affiliations

    • Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo 113-0033, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 5841 7872; fax: +81 3 5841 7873.
    • ,
  • Yoshiko Takahashi

      Affiliations

    • Department of Health and Nutrition, School of Home Economics, Wayo Women's University, Chiba 272-8533, Japan
    • ,
  • Kazuhiro Uenishi

      Affiliations

    • Laboratory of Physiological Nutrition, Kagawa Nutrition University, Saitama 350-0288, Japan
    • ,
  • Tomoko Watanabe

      Affiliations

    • Department of Nutrition, Chiba College of Health Science, Chiba 261-0014, Japan
    • ,
  • Toshiyuki Kohri

      Affiliations

    • Department of Food Science and Nutrition, School of Agriculture, Kinki University, Nara 631-8505, Japan
    • ,
  • Mitsuyo Yamasaki

      Affiliations

    • Department of Health and Nutrition Science, Faculty of Health and Social Welfare Science, Nishikyushu University, Saga 842-8585, Japan
    • ,
  • Reiko Watanabe

      Affiliations

    • Department of Human Life Environments, Course of Food and Nutrition, Niigata Women's College, Niigata 950-8680, Japan
    • ,
  • Keiko Baba

      Affiliations

    • Department of Nutrition, Mie Chukyo University Junior College, Mie 515-8511, Japan
    • ,
  • Katsumi Shibata

      Affiliations

    • Department of Life Style Studies, Laboratories of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Shiga 522-8533, Japan
    • ,
  • Toru Takahashi

      Affiliations

    • Graduate School of Human Life Science, Mimasaka University, Okayama 708-8511, Japan
    • ,
  • Hitomi Hayabuchi

      Affiliations

    • Department of Human Environmental Science, Fukuoka Women's University, Fukuoka 813-8529, Japan
    • ,
  • Kazuko Ohki

      Affiliations

    • Graduate School of Science for Living System, Showa Women's University, Tokyo 154-8533, Japan
    • ,
  • Junko Suzuki

      Affiliations

    • Department of Health and Nutrition, Faculty of Human Sciences, Hokkaido Bunkyo University, Hokkaido 061-1449, Japan

Received 14 July 2008 ,Revised 20 August 2008 ,Accepted 26 August 2008.

References 

  1. Vessby B, Gustafsson IB, Tengblad S, Boberg M, Andersson A. Desaturation and elongation of fatty acids and insulin action. Ann N Y Acad Sci. 2002;967:183–195
  2. Jeffcoat R. The biosynthesis of unsaturated fatty acids and its control in mammalian liver. Essays Biochem. 1979;15:1–36
  3. Warensjo E, Riserus U, Vessby B. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia. 2005;48:1999–2005
  4. Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ, Campbell LV. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med. 1993;328:238–244
  5. Warensjo E, Ohrvall M, Vessby B. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr Metab Cardiovasc Dis. 2006;16:128–136
  6. Stumvoll M. Control of glycaemia: from molecules to men. Minkowski Lecture 2003. Diabetologia. 2004;47:770–781
  7. Byberg L, Smedman A, Vessby B, Lithell H. Plasminogen activator inhibitor-1 and relations to fatty acid composition in the diet and in serum cholesterol esters. Arterioscler Thromb Vasc Biol. 2001;21:2086–2092
  8. Pan DA, Lillioja S, Milner MR, Kriketos AD, Baur LA, Bogardus C, et al. Skeletal muscle membrane lipid composition is related to adiposity and insulin action. J Clin Invest. 1995;96:2802–2808
  9. Salomaa V, Ahola I, Tuomilehto J, Aro A, Pietinen P, Korhonen HJ, et al. Fatty acid composition of serum cholesterol esters in different degrees of glucose intolerance: a population-based study. Metabolism. 1990;39:1285–1291
  10. Attie AD, Krauss RM, Gray-Keller MP, Brownlie A, Miyazaki M, Kastelein JJ, et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res. 2002;43:1899–1907
  11. Shiwaku K, Hashimoto M, Kitajima K, Nogi A, Anuurad E, Enkhmaa B, et al. Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians. J Lipid Res. 2004;45:914–922
  12. Wilson PW, D'Agostino RB, Parise H, Sullivan L, Meigs JB. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation. 2005;112:3066–3072
  13. Daviglus ML, Stamler J, Pirzada A, Yan LL, Garside DB, Liu K, et al. Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality. JAMA. 2004;292:1588–1592
  14. Lorenzo C, Okoloise M, Williams K, Stern MP, Haffner SM, San Antonio Heart Study . The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study. Diabetes Care. 2003;26:3153–3159
  15. Iso H, Sato S, Folsom AR, Shimamoto T, Terao A, Munger RG, et al. Serum fatty acids and fish intake in rural Japanese, urban Japanese, Japanese American and Caucasian American men. Int J Epidemiol. 1989;18:374–381
  16. Ueshima H, Stamler J, Elliott P, Chan Q, Brown IJ, Carnethon MR, et al. Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. Hypertension. 2007;50:313–319
  17. Murakami K, Sasaki S, Takahashi Y, Uenishi K, Yamasaki M, Hayabuchi H, et al. Total n-3 polyunsaturated fatty acid intake is inversely associated with serum C-reactive protein in young Japanese women. Nutr Res. 2008;28:309–314
  18. Kojima M, Wakai K, Tokudome S, Suzuki K, Tamakoshi K, Watanabe Y, et al. Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study. Am J Epidemiol. 2005;161:462–471
  19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  20. Ainsworth BE, Haskell WL, Leon AS, Jacobs DR, Montoye HJ, Sallis JF, et al. Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993;25:71–80
  21. Sasaki S, Yanagibori R, Amano K. Self-administered diet history questionnaire developed for health education: a relative validation of the test-version by comparison with 3-day diet record in women. J Epidemiol. 1998;8:203–215
  22. Sasaki S, Ushio F, Amano K, Morihara M, Todoriki T, Uehara Y, et al. Serum biomarker-based validation of a self-administered diet history questionnaire for Japanese subjects. J Nutr Sci Vitaminol. 2000;46:285–296
  23. Science and Technology Agency . Standard Tables of Food Composition in Japan, Fatty Acid Section. 5th revised and enlarged ed.. Tokyo: Printing Bureau of the Ministry of Finance; 2005;[in Japanese]
  24. Inoue S, Zimmet P, Bassett J. The Asia-Pacific perspective: redefining obesity and its treatment. Melbourne: World Health Organization; 2000;
  25. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults . Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  26. Yang EJ, Kerver JM, Park YK, Kayitsinga J, Allison DB, Song WO. Carbohydrate intake and biomarkers of glycemic control among US adults: the third National Health and Nutrition Examination Survey (NHANES III). Am J Clin Nutr. 2003;77:1426–1433
  27. Marques-Vidal P, Mazoyer E, Bongard V, Gourdy P, Ruidavets JB, Drouet L, et al. Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers. Diabetes Care. 2002;25:1371–1377
  28. Arab L. Biomarkers of fat and fatty acid intake. J Nutr. 2003;133:925S–932S
  29. Astorg P, Bertrais S, Laporte F, Arnault N, Estaquio C, Galan P, et al. Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. Eur J Clin Nutr. 2008;62:1155–1161
  30. von Houwelingen AC, Kester AD, Kromhout D, Hornstra G. Comparison between habitual intake of polyunsaturated fatty acids and their concentrations in serum lipid fractions. Eur J Clin Nutr. 1989;43:11–20
  31. Nikkari T, Salo M, Maatela J, Aromaa A. Serum fatty acids in Finnish men. Atherosclerosis. 1983;49:139–148
  32. Boberg M, Vessby B, Croon LB. Fatty acid composition of platelets and of plasma lipid esters in relation to platelet function in patients with ischaemic heart disease. Atherosclerosis. 1985;58:49–63
  33. Ministry of Health, Labour and Welfare of Japan . The National Health and Nutrition Survey in Japan, 2003. Tokyo: Daiichi Shuppan Publishing Co., Ltd.; 2006;[in Japanese]

PII: S0271-5317(08)00196-6

doi: 10.1016/j.nutres.2008.08.009

Nutrition Research
Volume 28, Issue 12 , Pages 816-824 , December 2008

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