Nutrition Research
Volume 28, Issue 12 , Pages 825-833 , December 2008

Long-term consumption of a carbohydrate-restricted diet does not induce deleterious metabolic effects

  • Paweł Grieb

      Affiliations

    • Department of Experimental Pharmacology, Polish Academy of Sciences Medical Research Center in Warsaw, 02-106 Warsaw, Poland
  • ,
  • Barbara Kłapcińska

      Affiliations

    • Department of Physiological and Medical Sciences, Academy of Physical Education, 40-065 Katowice, Poland
    • Corresponding Author InformationCorresponding author. Tel.: +48 207 5158; fax: +48 251 6868.
  • ,
  • Ewelina Smol

      Affiliations

    • Department of Physiological and Medical Sciences, Academy of Physical Education, 40-065 Katowice, Poland
  • ,
  • Tomasz Pilis

      Affiliations

    • Department of Physical Education and Sports, Jan Dlugosz University, 42-217 Częstochowa, Poland
  • ,
  • Wiesław Pilis

      Affiliations

    • Department of Physical Education and Sports, Jan Dlugosz University, 42-217 Częstochowa, Poland
  • ,
  • Ewa Sadowska-Krępa

      Affiliations

    • Department of Physiological and Medical Sciences, Academy of Physical Education, 40-065 Katowice, Poland
  • ,
  • Andrzej Sobczak

      Affiliations

    • Department of General and Analytical Chemistry, Faculty of Pharmacy, Medical University of Silesia, 41-200 Sosnowiec, Poland
  • ,
  • Zbigniew Bartoszewicz

      Affiliations

    • Department of Endocrinology, Medical University of Warsaw, 02-097 Warsaw, Poland
  • ,
  • Janusz Nauman

      Affiliations

    • Department of Endocrinology, Polish Academy of Sciences Medical Research Center in Warsaw, 02-106 Warsaw, Poland
  • ,
  • Kinga Stańczak

      Affiliations

    • Department of Experimental Pharmacology, Polish Academy of Sciences Medical Research Center in Warsaw, 02-106 Warsaw, Poland
  • ,
  • Józef Langfort

      Affiliations

    • Department of Experimental Pharmacology, Polish Academy of Sciences Medical Research Center in Warsaw, 02-106 Warsaw, Poland
    • Department of Physiological and Medical Sciences, Academy of Physical Education, 40-065 Katowice, Poland

Received 6 July 2008 ,Revised 27 September 2008 ,Accepted 30 September 2008.

References 

  1. Strychar I. Diet in the management of weight loss. CMAJ. 2006;174:56–63
  2. Crowe TC. Safety of low-carbohydrate diets. Obesity. 2005;6:235–245
  3. Atkins RC. Dr. Atkins' new diet revolution. London: Vermillion; 2003;
  4. Kwaśniewski J., Chyliński M., Homo optimus. WGP Publishing; 2000; also available at http://homodiet.netfirms.com/
  5. Kothari S, Saperia G. Is a low-carbohydrate diet good for the heart? A review. Am J Clin Med. 2005;2:4–10
  6. Feinman RD, Volek JS. Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss. Nutr Metab (Lond). 2006;3:24
  7. Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WS, Brehm BJ, et al. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006;166:285–293
  8. Wood RJ, Volek JS, Davis SR, Dell'Ova C, Luz Fernandez M. Effects of a carbohydrate-restricted diet on emerging plasma markers for cardiovascular disease. Nutr Metab (Lond). 2006;3:19
  9. Foster GD, Wyatt HR, Hill JO, McGuckin BG, Brill C, Mohammed BS, et al. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med. 2003;348:2082–2090
  10. Bravata DM, Sanders L, Huang J, Krumholz HM, Olkin I, Gardner CD, et al. Efficacy and safety of low-carbohydrate diets: a systematic review. JAMA. 2003;289:1837–1850
  11. Stern L, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med. 2004;140:778–785
  12. Dashti HM, Al-Zaid NS, Mathew TC, Al-Mousawi M, Talib H, Asfar SK, et al. Long-term effects of ketogenic diet in obese subjects with high cholesterol level. Mol Cell Biochem. 2006;286:1–9
  13. Nielsen JV, Joensson E. Low-carbohydrate diet in type 2 diabetes. Stable improvement of bodyweight and glycemic control during 22 months follow-up. Nutr Metab (Lond). 2006;3:22
  14. Feinman RD, Vernon MC, Westman EC. Low carbohydrate diets in family practice: what can we learn from an internet-based support group. Nutr J. 2006;5:26
  15. Fatouros JG, Goldfarb AH, Jamurtas AZ. Low carbohydrate diet induces changes in central and peripheral beta-endorphins. Nutr Res. 1995;15:1683–1694
  16. Williamson DH, Mellanby J, Krebs HA. Enzymatic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in blood. Biochem J. 1962;82:90–96
  17. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–505
  18. Wallace TM, Matthews DR. The assessment of insulin resistance in man. Diabet Med. 2002;19:527-534
  19. McLaughlin T, Reaven G, Abbasi F, Lamendola C, Saad M, Waters D, et al. Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?. Am J Cardiol. 2005;96:399–404
  20. Schipchandler MT, Moore EG. Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. Clin Chem. 1995;41:991–994
  21. Sobczak A, Skop B, Kula B. Simultaneous determination of serum retinol and alpha- and gamma-tocopherol levels in type II diabetic patients using high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl. 1999;730:265–271
  22. Tatzber F, Esterbauer H. Autoantibodies to oxidized low-density lipoprotein. In:  Bellomo G,  Finardi E,  Maggi E,  Rice-Evans C editor. Free Radicals IX. London: Richelieu Press; 1995;p. 245–262
  23. Altman DG. Practical statistics for medical research. Chapman&Hall/CRC; 1991;
  24. National Research Council Recommended Dietary Allowances . Subcommittee on the Tenth Edition of the RDAs Food and Nutrition Board, Commission on Life Sciences 10th ed. Washington, DC: National Academy Press; 1989;
  25. Morrissey PA, Sheehy PJ. Optimal nutrition: vitamin E. Proc Nutr Soc. 1999;58:459–468
  26. Gey KF. Cardiovascular disease and vitamins. Concurrent correction of “suboptimal” plasma antioxidant levels may, as important part of “optimal” nutrition, help to prevent early stages of cardiovascular disease and cancer, respectively. Bibl Nutr Dieta. 1995;52:75–91
  27. Selhub J, Jacques PF, Rosenberg IH, Rogers G, Bowman BA, Gunter EW, et al. Serum total homocysteine concentrations in the Third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med. 1999;131:331–339
  28. Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107:363–369
  29. Westman EC, Feinman RD, Mavropoulos JC, Vernon MC, Volek JS, Wortman JA, et al. Low carbohydrate nutrition and metabolism. Am J Clin Nutr. 2007;86:276–284
  30. Freedman MR, King J, Kennedy E. Popular diets: a scientific review. Obes Res. 2001;9(Suppl 1):1S–40S
  31. Adam-Perrot A, Clifton P, Brouns F. Low-carbohydrate diets: nutritional and physiological aspects. Obes Rev. 2006;7:49–58
  32. Blomqvist G, Thorell JO, Ingvar M, Grill V, Widen L, Stone-Elander S. Use of R-beta-[1-11C]hydroxybutyrate in PET studies of regional cerebral uptake of ketone bodies in humans. Am J Physiol. 1995;269:E948–E959
  33. Bobulescu IA, Moe OW. Na+/H+ exchangers in renal regulation of acid-base balance. Semin Nephrol. 2006;26:334–344
  34. Shafiee MA, Kamel KS, Halperin ML. A conceptual approach to the patient with metabolic acidosis. Nephron. 2002;92(Suppl 1):46–55
  35. Yancy WS, Olsen MK, Guyton JR, Bakst RP, Westman EC. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia. A randomized, controlled trial. Ann Intern Med. 2004;140:769–777
  36. Brehm BJ, Seeley RJ, Daniels SR, D'Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab. 2003;88:1617–1623
  37. Volek JS, Feinman RD. Carbohydrate restriction improves the features of metabolic syndrome. Metabolic syndrome may be defined by the response to carbohydrate restriction. Nutr Metab (Lond). 2005;2:31
  38. Noakes M, Foster PR, Keogh JB, James AP, Mamo JC, Clifton PM. Comparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular risk. Nutr Metab (Lond). 2006;3:7
  39. Volek JS, Forsythe CE. The case for not restricting saturated fat on a low carbohydrate diet. Nutr Metab (Lond). 2005;2:21
  40. Schaefer EJ. Lipoproteins, nutrition and heart disease. Am J Clin Nutr. 2002;75:191–212
  41. Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr. 2003;77:1146–1155
  42. Natarajan S, Glick H, Criqui M, Horowitz D, Lipsitz SR, Kinosian B. Cholesterol measures to identify and treat individuals at risk for coronary heart disease. Am J Prev Med. 2003;25:50–57
  43. Kinosian B, Glick H, Garland G. Cholesterol and coronary heart disease: predicting risks by levels and ratios. Ann Intern Med. 1994;121:641–647
  44. Inoue T, Uchida T, Kamishirado H, Takayanagi K, Hayashi T, Morooka S. Clinical significance of antibody against oxidized low density lipoprotein in patients with atherosclerotic coronary artery disease. J Am Coll Cardiol. 2001;37:559–775
  45. Pincemail J, Siquet J, Chapelle JP, Cheramy-Bien JP, Paulissen G, Chantillon AM, et al. Determination of concentrations of antioxidants, antibodies against oxidized LDL, and homocysteine in a population sample from Liège. Ann Biol Clin (Paris) (in French). 2000;58:177–185
  46. Jialal I, Fuller CJ, Huet BA. The effect of α-tocopherol supplementation on LDL oxidation. Arterioscler Thromb Vasc Biol. 1995;15:190–198
  47. Kaul N, Devaraj S, Jialal I. α-Tocopherol and atherosclerosis. Exp Biol Med. 2001;226:5–12
  48. Pollok D. Bestimmung von Tocopheroloxidationsprodukten in Humanserum. Diplom Dissertation, Berlin; 2004.
  49. Jiang Q, Christen S, Shigenaga MK, Ames BN. γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001;74:714–722
  50. Arora SK, Yancy WS, Foy M, Chalecki AM, Vernon MC, Westman EC. A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutr Metab (Lond). 2005;2:34
  51. Nielsen JV, Joensson E. Low-carbohydrate diet in type 2 diabetes. Stable improvement of bodyweight and glycemic control during 22 months follow-up. Nutr Metab (Lond). 2006;3:22
  52. Worth J, Soran H. Is there a role for low carbohydrate diets in the management of type 2 diabetes. QJM. 2007;100:659–663
  53. Rewers M, Zaccaro D, D'Agostino R, Haffner S, Saad MF, Selby JV, et al. Insulin sensitivity, insulinemia, and coronary artery disease. The insulin resistance atherosclerosis study. Diabetes Care. 2004;27:781–787
  54. Hanley AJG, Williams K, Stern MP, Haffner SM. Homeostasis model assessment of insulin resistance in relation tot the incidence of cardiovascular disease. The San Antonio Heart Study. Diabetes Care. 2002;25:1177–1184
  55. De Bree A, Verschuren WM, Kromhout D, Kluijtmans LA, Blom HJ. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev. 2002;54:599–618
  56. Labarrere CA, Zaloga GP. C-reactive protein: from innocent bystander to pivotal mediator of atherosclerosis. Am J Med. 2004;117:499–507
  57. Nurk E, Tell GS, Vollset SE, Nygård O, Refsum H, Nilsen RM, et al. Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study. Am J Clin Nutr. 2004;79:812–819
  58. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, et al. C-Reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004;350:1387–1397
  59. Fredrikson GN, Hedblad B, Nilsson JA, Alm R, Berglund G, Nilsson J. Association between diet, lifestyle, metabolic cardiovascular risk factors, and plasma C-reactive protein levels. Metabolism. 2004;53:1436–1442
  60. Seshadri P, Iqbal N, Stern L, Williams M, Chicano KL, Daily DA, et al. A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity. Am J Med. 2004;117:398–405

PII: S0271-5317(08)00213-3

doi: 10.1016/j.nutres.2008.09.011

Nutrition Research
Volume 28, Issue 12 , Pages 825-833 , December 2008