Nutrition Research
Volume 29, Issue 1 , Pages 26-34 , January 2009

A low pretransplant peripheral blood mononuclear cell complex I activity predicts metabolic disturbances and inability to regain fat free mass in cirrhotic patients undergoing liver transplantation

  • Francoise Briet

      Affiliations

    • Department of Anesthesia, the Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada M5B 1W8
    • Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding authors. Francoise Briet is to be contacted at Anesthesia Department, St. Michael's Hospital, Toronto, ON, Canada M5B 1W8. Tel.: +1 416 360 4000x2920; fax: +1 416 864 6014. James Scolapio, Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville , FL 32224, USA. Tel.: +1 904 953 2221; fax: +1 904 953 7260.
  • ,
  • Bashar A. Aqel

      Affiliations

    • Division of Hepatology and Gastroenterology, Department of Medicine, Mayo Clinic, Jacksonville , FL, USA
  • ,
  • Khursheed N. Jeejeebhoy

      Affiliations

    • Division of Gastroenterology, St Michael’s Hospital, Toronto, Ontario, Canada
    • Department of Medicine, University of Toronto, Toronto, Ontario, Canada
  • ,
  • James S. Scolapio

      Affiliations

    • Division of Hepatology and Gastroenterology, Department of Medicine, Mayo Clinic, Jacksonville , FL, USA
    • Corresponding Author InformationCorresponding authors. Francoise Briet is to be contacted at Anesthesia Department, St. Michael's Hospital, Toronto, ON, Canada M5B 1W8. Tel.: +1 416 360 4000x2920; fax: +1 416 864 6014. James Scolapio, Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville , FL 32224, USA. Tel.: +1 904 953 2221; fax: +1 904 953 7260.

Received 11 May 2008 ,Revised 20 October 2008 ,Accepted 20 October 2008.

References 

  1. Tsiaousi ET, Hatzitolios AI, Trygonis SK, Savopoulos CG. Malnutrition in end stage liver disease: recommendations and nutritional support. J Gastroenterol Hepatol. 2008;23:527–533
  2. Gunsar F, Raimondo ML, Jones S, Terreni N, Wong C, Patch D, et al. Nutritional status and prognosis in cirrhotic patients. Aliment Pharmacol Ther. 2006;24:563–572
  3. Alberino F, Gatta A, Amodio P, Merkel C, Di Pascoli L, Boffo G, et al. Nutrition and survival in patients with liver cirrhosis. Nutrition. 2001;17:445–450
  4. Bismuth H, Farges O, Castaing D, Samuel D, Adam R, Johann M, et al. Evaluation of results of liver transplantation: experience based on a series of 1052 transplantations. Presse Med. 1995;24:1106–1114
  5. Wood RP, Ozaki CF, Katz SM, Monsour HP, Dyer CH, Johnston TD. Liver transplantation. The last ten years. Surg Clin North Am. 1994;74:1133–1154
  6. Loss M, Winkler M, Schneider A, Brinkmann C, Manns M, Ringe B, et al. Influence of long-term cyclosporine or FK 506 therapy on glucose and lipid metabolism in stable liver graft recipients. Transplant Proc. 1995;27:1136–1139
  7. Stegall MD, Everson G, Schroter G, Bilir B, Karrer F, Kam I. Metabolic complications after liver transplantation. Diabetes, hypercholesterolemia, hypertension, and obesity. Transplantation. 1995;60:1057–1060
  8. Tappy L, Schneiter P, Chiolero R, Bettschart V, Gillet M. Effects of a glucose meal on energy metabolism in patients with cirrhosis before and after liver transplantation. Arch Surg. 2001;136:80–84
  9. Nair S, Verma S, Thuluvath PJ. Obesity and its effect on survival in patients undergoing orthotopic liver transplantation in the United States. Hepatology. 2002;35:105–109
  10. Munoz SJ, Deems RO, Moritz MJ, Martin P, Jarrell BE, Maddrey WC. Hyperlipidemia and obesity after orthotopic liver transplantation. Transplant Proc. 1991;23:1480–1483
  11. Hussaini SH, Soo S, Stewart SP, Oldroyd B, Roman F, Smith MA, et al. Risk factors for loss of lean body mass after liver transplantation. Appl Radiat Isot. 1998;49:663–664
  12. Matos C, Porayko MK, Francisco-Ziller N, DiCecco S. Nutrition and chronic liver disease. J Clin Gastroenterol. 2002;35:391–397
  13. McCullough AJ. Malnutrition in liver disease. Liver Transpl. 2000;6:S85–S96
  14. McCullough AJ, Mullen KD, Smanik EJ, Tabbaa M, Szauter K. Nutritional therapy and liver disease. Gastroenterol Clin North Am. 1989;18:619–643
  15. Henkel AS, Buchman AL. Nutritional support in patients with chronic liver disease. Nat Clin Pract Gastroenterol Hepatol. 2006;3:202–209
  16. Briet F, Twomey C, Jeejeebhoy KN. Effect of malnutrition and short-term refeeding on peripheral blood mononuclear cell mitochondrial complex I activity in humans. Am J Clin Nutr. 2003;77:1304–1311
  17. Briet F, Twomey C, Jeejeebhoy KN. Relationship between metabolism and peripheral blood mononuclear cell mitochondrial complex I activity before and after a short-term refeeding in weight-losing cancer patients. Clin Nutr. 2003;22:247–253
  18. Briet F, Twomey C, Jeejeebhoy KN. Effect of feeding malnourished patients for 1 mo on mitochondrial complex I activity and nutritional assessment measurements. Am J Clin Nutr. 2004;79:787–794
  19. Frisancho AR. Triceps skin fold and upper arm muscle size norms for assessment of nutrition status. Am J Clin Nutr. 1974;27:1052–1058
  20. Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr. 1974;32:77–97
  21. Frisancho AR. New norms of upper limb fat and muscle areas for assessment of nutritional status. Am J Clin Nutr. 1981;34:2540–2545
  22. Riggio O, Andreoli A, Diana F, Fiore P, Meddi P, Lionetti R, et al. Whole body and regional body composition analysis by dual-energy x-ray absorptiometry in cirrhotic patients. Eur J Clin Nutr. 1997;51:810–814
  23. Plank LD. Dual-energy x-ray absorptiometry and body composition. Curr Opin Clin Nutr Metab Care. 2005;8:305–309
  24. Briet F, Jeejeebhoy KN. Effect of hypoenergetic feeding and refeeding on muscle and mononuclear cell activities of mitochondrial complexes I–IV in enterally fed rats. Am J Clin Nutr. 2001;73:975–983
  25. Larson MG. Analysis of variance. Circulation. 2008;117:115–121
  26. Ioannou GN, Weiss NS, Kowdley KV, Dominitz JA. Is obesity a risk factor for cirrhosis-related death or hospitalization? A population-based cohort study. Gastroenterology. 2003;125:1053–1059
  27. Wilson MM, Morley JE. Invited review: aging and energy balance. J Appl Physiol. 2003;95:1728–1736
  28. Chang WK, Chao YC, Tang HS, Lang HF, Hsu CT. Effects of extra-carbohydrate supplementation in the late evening on energy expenditure and substrate oxidation in patients with liver cirrhosis. JPEN J Parenter Enteral Nutr. 1997;21:96–99
  29. Sanchez-Rodriguez A, Criado M, Rodriguez-Lopez AM, Esteller A, Martin de Arriba A, Lopez-Novoa JM. Increased nitric oxide synthesis and inducible nitric oxide synthase expression in patients with alcoholic and non-alcoholic liver cirrhosis. Clin Sci (Lond). 1998;94:637–643
  30. Parvu AE, Negrean V, Plesca-Manea L, Cosma A, Draghici A, Uifalean A, et al. Nitric oxide in patients with chronic liver diseases. Rom J Gastroenterol. 2005;14:225–230
  31. Clementi E, Brown GC, Feelisch M, Moncada S. Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci U S A. 1998;95:7631–7636
  32. Siqueira C, de Moura MC, Pedro AJ, Rocha P. Elevated nitric oxide and 3′,5′ cyclic guanosine monophosphate levels in patients with alcoholic cirrhosis. World J Gastroenterol. 2008;14:236–242
  33. Porayko MK, DiCecco S, O'Keefe SJ. Impact of malnutrition and its therapy on liver transplantation. Semin Liver Dis. 1991;11:305–314
  34. Delafosse B, Faure JL, Bouffard Y, Viale JP, Goudable J, Annat G, et al. Liver transplantation—energy expenditure, nitrogen loss, and substrate oxidation rate in the first two postoperative days. Transplant Proc. 1989;21:2453–2454
  35. Plank LD, Metzger DJ, McCall JL, Barclay KL, Gane EJ, Streat SJ, et al. Sequential changes in the metabolic response to orthotopic liver transplantation during the first year after surgery. Ann Surg. 2001;234:245–255
  36. van den Ham EC, Kooman JP, Christiaans MH, Leunissen KM, van Hooff JP. Posttransplantation weight gain is predominantly due to an increase in body fat mass. Transplantation. 2000;70:241–242
  37. van den Ham EC, Kooman JP, Christiaans MH, van Hooff JP. Relation between steroid dose, body composition and physical activity in renal transplant patients. Transplantation. 2000;69:1591–1598
  38. Houmard JA. Intramuscular lipid oxidation and obesity. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1111–R1116
  39. Evans WJ. Exercise and nutritional needs of elderly people: effects on muscle and bone. Gerodontology. 1998;15:15–24

 This study was supported in part by the following grants: MRC grant MT-10885 and Mayo clinic Funding.

PII: S0271-5317(08)00225-X

doi: 10.1016/j.nutres.2008.10.004

Nutrition Research
Volume 29, Issue 1 , Pages 26-34 , January 2009