Nutrition Research
Volume 29, Issue 1 , Pages 49-54 , January 2009

In vitro intestinal glucose uptake is inhibited by galactomannan from Canadian fenugreek seed (Trigonella foenum graecum L) in genetically lean and obese rats

  • Anchalee Srichamroen

      Affiliations

    • Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    • ,
  • Alan B.R. Thomson

      Affiliations

    • Division of Gastroenterology, Zeidler Ledcor Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2X8
    • ,
  • Catherine J. Field

      Affiliations

    • Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    • ,
  • Tapan K. Basu

      Affiliations

    • Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    • Corresponding Author InformationCorresponding author. Tel.: +1 780 492 5338; fax: +1 780 492 4265.

Received 2 August 2008 ,Revised 21 November 2008 ,Accepted 22 November 2008.

References 

  1. Rao PU, Sesikeran B, Rao PS, Naidu AN, Rao VV, Ramacjandran EP. Short-term nutritional and safety evaluation of fenugreek. Nutr Res. 1996;16:1495–1505
  2. Raghuram TC, Sharma RD, Sivakumar B. Effect of fenugreek seeds on intravenous glucose disposition in non-insulin dependent diabetic patients. Phytother Res. 1994;8:83–86
  3. Khosla P, Gupta DD, Nagpal RK. Effect of Trigonella foenum graecum (fenugreek) on blood glucose in normal and diabetic rats. Indian J Physiol Pharmacol. 1995;39(2):173–174
  4. Mardar Z. Fenugreek (Trigonella foenum graecum) as a means of reducing postprandial glucose level in diabetic rats. Nutr Rep Inter. 1984;29:1267–1273
  5. Sharma RD. Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr Res. 1986;6:1353–1364
  6. Sharma RD, Sarkar A, Hazra DK, Mishara B, Singh JB, Sharma SK, et al. Use of fenugreek seed powder in the management of non-insulin dependent diabetes mellitus. Nutr Res. 1996;16:1331–1339
  7. Srichamroen A, Field CJ, Thomson ABR, Basu TK. The modifying effect of galactomannan from Canadian-grown fenugreek (Trigonella foenum-graecum L.) on the glycemic and lipidemic status in rats. J Clin Biochem Nutr. 2008;43:167–174
  8. Russell JC. Type 2 Diabetes: pharmacological intervention in an animal model. In:  Angel A editors. Diabetes and cardiovascular disease: etiology, treatment and outcomes. New York: Kluwer Academic: Plenum publishers; 2001;p. 295–302
  9. Deng X, Elam MB, Wilcox HG. Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR:LA-cp rats: microarray analysis of lipid-related gene expression. Endocrinology. 2004;145:5847–5861
  10. Thomson ABR. Resection of rabbit ileum: effect on jejunal structure and carrier-mediated and passive uptake. Q J Exp Physiol. 1986;71:29–46
  11. Thomson ABR. Unidirectional flux rate of cholesterol and fatty acids into the intestine of rats with drug-induced diabetes mellitus: effects of variations in the effective resistance of the unstirred water layer and the bile acid micelle. J Lipid Res. 1980;21:687–698
  12. Westergaard H, Dietschy JM. Delineation of the dimensions and permeability coefficients of the two major diffusion barriers to passive mucosal uptake in the rabbit intestine. J Clin Invest. 1974;54:718–732
  13. Cybulska B, Doe PE. Water and food quality. In:  Sikorski ZE editors. Chemical and functional properties of food components. 2nd ed.. London: CRC press; 2002;p. 25–50
  14. Knudsen JG, Hottel HC, Sarofim AF, Wankat PC, Knaebel KS. Heat and mass transfer. In:  Perry RH,  Green DW,  Maloney JO editor. Perry's chemical engineers' handbook. 7th ed.. McGraw-Hill: R.R. Donnelley and Sons Co.; 1997;p. 5–50
  15. Ferraris RP, Yasharpour S, Lloyd KCK, Mirzayan R, Diamond JM. Luminal glucose concentration in the gut under normal conditions. Am J Physiol. 1990;259:G822–G837
  16. Wilson FA, Dietschy JM. The intestinal unstirred layer: its surface area and effect on active transport kinetics. Biochim Biophys Acta. 1974;363:112–126
  17. Johnson IT, Gee JM. Effect of gel-forming gums on the intestinal unstirred layer and sugar transport in vitro. Gut. 1981;22:398–403
  18. Elfak AM, Pass G, Phillips GO, Morley RG. The viscosity of dilute solutions of guar gum and locust bean gum with and without added sugars. J Sci Fd Agric. 1977;28:895–899
  19. Doyle JP, Giannouli P, Martin EJ, Brooks M, Morris E. Effect of sugars, galactose content and chain length on freeze-thaw gelation of galactomannans. Carbohydr Polym. 2006;64:391–401

PII: S0271-5317(08)00250-9

doi: 10.1016/j.nutres.2008.11.002

Nutrition Research
Volume 29, Issue 1 , Pages 49-54 , January 2009

Article Tools

* Image Usage & Resolution