Nutrition Research
Volume 29, Issue 1 , Pages 19-25 , January 2009

Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults

  • Harunobu Amagase

      Affiliations

    • FreeLife International, LLC, Phoenix, AZ 85040, USA
    • ,
  • Buxiang Sun

      Affiliations

    • Department of Nutrition, University of California at Davis, Davis, CA 95616, USA
    • ,
  • Carmia Borek

      Affiliations

    • Department of Public Health and Family Medicine, Nutrition Infectious Disease Unit, Tufts University School of Medicine, Boston, MA 02111, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 781 267 4813.

Received 2 September 2008 ,Revised 22 November 2008 ,Accepted 25 November 2008.

References 

  1. Luo Q, Cai Y, Yan J, Sun M, Corke H. Hypoglycemic and hypolipidemic effects and anti-oxidant activity of fruit extracts from Lycium barbarum. Life Sci. 2004;76:137–149
  2. Borek C. Dietary antioxidants and human cancer. Integr Cancer Ther. 2004;3:333–341
  3. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Alt Comp Med. 2008;14:403–412
  4. Chang RC, So KF. Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far. Cell Mol Neurobiol. 2008;28(5):643–652
  5. Peng Y, Ma C, Li Y, Leung KS, Jiang ZH, Zhao Z. Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (fructus Lycii). Plant Foods Hum Nutr. 2005;60:161–164
  6. NHI. Gou Qi Zi, Lycium fruit, Lycii fructus http://content.nhiondemand.com/moh/media/TCMH1.asp?objID=100832&ctype=tcmh#fn111585; accessed on 11/20/2007.
  7. Wang Q. Determination of polysaccharide contents in fructus Lycii. Chin Tradit Herb Drugs. 1991;22:67–68
  8. Luo Q, Yan J, Zhang S. Isolation and purification of Lycium barbarum polysaccharides and its antifatigue effect. Wei Sheng Yan Jiu (J Hygiene Res). 2000;29:115–117
  9. Peng X, Tian G. Structural characterization of the glycan part of glycoconjugate LbGp2 from Lycium barbarum L. Carbohydr Res. 2001;331:95–99
  10. Peng XM, Wang ZF, Tian GY. Physico-chemical properties and activity of glycoconjugate LbGp2 from Lycium barbarum L. Yao Xue Xue Bao (Acta Pharmaceutica Sinica). 2001;36:599–602
  11. Tian M, Wang M. Studies on extraction, isolation and composition of Lycium barbarum polysaccharides. Zhongguo Zhong Yao Za Zhi (China J Chin Mat Med). 2006;31:1603–1607
  12. Chang R. Bioactive polysaccharides from traditional Chinese medicine herbs as anticancer adjuvants. J Alt Comp Med. 2002;8:559–565
  13. Wong CK, Leung KN, Fung KP, Choy YM. Immunomodulatory and anti-tumour polysaccharides from medicinal plants. J Int Med Res. 1994;22:299–312
  14. Martin JP, Dailey M, Sugarman E. Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys. 1987;255:329–336
  15. NWLSS Superoxide dismutase activity assay. http://www.nwlifescience.com/products/assaykit/sod02.htm accessed 3/8/2008.
  16. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70:158–169
  17. NWLSS Glutathione peroxidase (GPx) assay. http://www.nwlifescience.com/products/assaykit/gpx01.htm accessed 3/8/2008.
  18. Halliwell B, Gutteridge JMC. 4.9.4. Targets of attack: fatty acids and lipoproteins. In: Free radicals in biology and medicine. New York: Oxford University Press; 1999;p. 289–295
  19. NWLSS Malondialdehyde assay. http://www.nwlifescience.com/products/assaykit/mda01.htm. accessed 3/8/2008.
  20. Xin YF, Zhou GL, Deng ZY, Chen YX, Wu YG, Xu PS, et al. Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicity. Phytother Res. 2007;21:1020–1024
  21. Bensky D, Gamble A. Gou Qi Zi. In:  Grigston J editors. Chinese herbal medicine, Materia Medica revised edition. Seattle: Eastland Press; 1993;p. 333–334
  22. Huang Y, Lu J, Shen Y, Lu J. The protective effects of total flavonoids from Lycium barbarum L. on lipid peroxidation of liver mitochondria and red blood cell in rats. Wei Sheng Yan Jiu (J Hygiene Res). 1999;28:115–116
  23. Li G, Yang J, Ren B, Wang Z. Effect of Lycium barbarum L on defending free radicals of mice caused by hypoxia. Wei Sheng Yan Jiu (J Hygiene Res). 2002;31:30–31
  24. Li XM, Ma YL, Liu XJ. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J Ethnopharmacol. 2007;111:504–511
  25. Li XM. Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. Int J Biol Macromol. 2007;40:461–465
  26. Ni H, Qing D, Kaisa S, Lu J. The study on the effect of LBP on cleaning hydroxygen free radical by EPR technique. Zhong Yao Cai (J Chin Med Mat). 2004;27:599–600
  27. Wu SJ, Ng LT, Lin CC. Anti-oxidant activities of some common ingredients of traditional Chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos. Phytother Res. 2004;18:1008–1012
  28. Wu H, Guo H, Zhao R. Effect of Lycium barbarum polysaccharide on the improvement of anti-oxidant ability and DNA damage in NIDDM rats. Yakugaku Zasshi (J Pharmaceut Soc Jpn). 2006;126:365–371
  29. Wang Y, Zhao H, Sheng X, Gambino PE, Costello B, Bojanowski K. Protective effect of fructus lycii polysaccharides against time and hyperthermia-induced damage in cultured seminiferous epithelium. J Ethnopharmacol. 2002;82(2-3):169–175
  30. Huang LJ, Tian GY, Wang ZF, Dong JB, Wu MP. Studies on the glycoconjugates and glycans from Lycium barbarum L in inhibiting low density lipoprotein (LDL) peroxidation. Yao Xue Xue Bao (Acta pharmaceutica Sinica). 2001;36(2):108–111
  31. Sathya A, Prabhakar S, Sangha SP, Ghuman SP. Vitamin E and selenium supplementation reduces plasma cortisol and oxidative stress in dystocia-affected buffaloes. Vet Res Commun. 2007;31(7):809–818
  32. Bengmark S, Gil A. Bioecological and nutritional control of disease: prebiotics, probiotics and synbiotics. Nutr Hosp. 2006 May;21 Suppl 2:72-84, 73-86.
  33. Personal communication with Dr. Dwight Nance at University of California at Irvine.
  34. Ramanathan L, Gulyani S, Nienhuis R, Siegel JM. Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem. Neuroreport. 2002;13:1387–1390
  35. Andersen HR, Nielsen JB, Nielsen F, Grandjean P. Antioxidative enzyme activities in human erythrocytes. Clin Chem. 1997;43:562–568
  36. Wang XL, Adachi T, Sim AS, Wilcken EL. Plasma extracellular superoxide dismutase levels in an Australian population with coronary artery disease. Arthrioscler Thromb Vasc Biol. 1998;18:1915–1921
  37. Bose KSC, Agrawal BK. Effect of lycopene from tomatoes (cooked) on plasma anti-oxidant enzymes, lipid peroxidation rate and lipid profile in grade-I hypertension. Ann Nutr Metab. 2007;51:477–481
  38. Micke P, Beeh KM, Schlaak JF, Buhl R. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. Eur J Clin Invest. 2001;31:171–178
  39. Machefer G, Groussard C, Vincent S, Zouhal H, Faure H, Cillard J, et al. Multivitamin-mineral supplementation prevents lipid peroxidation during “The Marathon des Sables”. J Am Col Nutr. 2007;26:111–120

PII: S0271-5317(08)00251-0

doi: 10.1016/j.nutres.2008.11.005

Nutrition Research
Volume 29, Issue 1 , Pages 19-25 , January 2009

Article Tools