G allele at RAGE SNP82 is associated with proinflammatory markers in obese subjects

Kim, Oh Yoen; Jo, Seog Hyun; Jang, Yangsoo; Chae, Jey Sook; Kim, Ji Young; Hyun, Yae Jung; Lee, Jong Ho

doi:10.1016/j.nutres.2009.01.006

« Previous Next »Nutrition Research
Volume 29, Issue 2 , Pages 106-113, February 2009

G allele at RAGE SNP82 is associated with proinflammatory markers in obese subjects

Oh Yoen Kim
- Clinical Nutrigenetics/Nutrigenomics Lab, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 120-749 Seoul, Korea
- Yonsei University Research Institute of Science for Aging, Yonsei University, 120-749 Seoul, Korea
- These authors contributed equally to this work.
Seog Hyun Jo
- Interdisciplinary program: Science for Aging, The Graduate School, Yonsei University, 120-749 Seoul, Korea
- These authors contributed equally to this work.
Yangsoo Jang
- Yonsei University Research Institute of Science for Aging, Yonsei University, 120-749 Seoul, Korea
- Interdisciplinary program: Science for Aging, The Graduate School, Yonsei University, 120-749 Seoul, Korea
- Division of Cardiology, Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei University, 120-749 Seoul, Korea
Jey Sook Chae
- Clinical Nutrigenetics/Nutrigenomics Lab, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 120-749 Seoul, Korea
- Yonsei University Research Institute of Science for Aging, Yonsei University, 120-749 Seoul, Korea
Ji Young Kim
- Clinical Nutrigenetics/Nutrigenomics Lab, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 120-749 Seoul, Korea
- Yonsei University Research Institute of Science for Aging, Yonsei University, 120-749 Seoul, Korea
Yae Jung Hyun
- Clinical Nutrigenetics/Nutrigenomics Lab, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 120-749 Seoul, Korea
- Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University College of Human Ecology, 120-749 Seoul, Korea
Jong Ho Lee
- Clinical Nutrigenetics/Nutrigenomics Lab, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 120-749 Seoul, Korea
- Yonsei University Research Institute of Science for Aging, Yonsei University, 120-749 Seoul, Korea
- Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University College of Human Ecology, 120-749 Seoul, Korea
- Corresponding author. Department of Food and Nutrition, College of Human Ecology, Yonsei University, 134 Shinchon-dong, Sudaemun-gu, Seoul 120-749, Korea. Tel.: +82 2 2123 3122; fax: +82 2 364 9605.

Received 15 September 2008; received in revised form 20 December 2008; accepted 26 January 2009.

Abstract

Obesity is closely associated with low-grade inflammation. The Gly82Ser (G82S) polymorphism in the receptor for the advanced glycation end products (RAGE) gene related to RAGE expression is also involved in inflammatory response. We examined the association between RAGEG82S and obesity on soluble RAGE (sRAGE) and inflammatory markers in Korean men. The following were measured: anthropometric and biochemical parameters, RAGEG82S polymorphism, sRAGE, advanced glycation end products (AGEs), and inflammatory markers in men (n = 1252; range, 30-70 years; body mass index [BMI], ≥18.5 kg/m²). Allele frequencies satisfied Hardy-Weinberg Equilibrium (G/G: 72.2%, G/S: 25.5%, S/S: 2.3%). RAGEG82S (β-coefficient = −0.384, P < .001) and BMI (β-coefficient = −0.168, P = .001) were major factors affecting sRAGE concentrations. In all subjects, those with ‘S/S’ homozygotes showed the lowest levels of sRAGE (G/G: 1036.3 ± 40.3, G/S: 807.0 ± 49.6, S/S: 443.0 ± 47.8 pg/mL) before (P < .001) and after adjusted for age, BMI, cigarette smoking, and alcohol drinking (P < .001). When subdivided according to BMI of 25 kg/m² (Asian Pacific guideline), obese subjects (BMI ≥25 kg/m²) had significantly lower levels of sRAGE (831.7 ± 36.7 vs 1022.7 ± 47.8 pg/mL, P = .009) and higher levels of high sensitivity C-reactive protein (hs-CRP) (1.10 ± 0.07 vs 0.72 ± 0.05 mg/dL, P < .001) compared with nonobese subjects (BMI <25 kg/m²). Particularly in obese subjects, S/S carriers showed significantly higher concentrations of AGEs (P = .012) and hs-CRP (P = .006) than G allele carriers, whereas nonobese people had no significant RAGEG82S-related differences in AGEs (P = .743) and hs-CRP (P = .436). In conclusion, G allele at RAGEG82S may be more associated with inflammatory markers under obese status than nonobese conditions. In this case, it may help to suggest proper dietary modification for controlling obesity to people with genetic variants.