Nutrition Research
Volume 29, Issue 6 , Pages 419-425 , June 2009

Hydrolyzed guar gum decreases postprandial blood glucose and glucose absorption in the rat small intestine

  • Toru Takahashi

      Affiliations

    • Faculty of Human Life Science, Mimasaka University, Tsuyama, Okayama 708 8511, Japan
    • Corresponding Author InformationCorresponding author. Faculty of Human Life Science, Mimasaka University, 50 Kitazono, Tsuyama, Okayama 708 8511, Japan. Tel.: +81 868 22 7718 (295); fax: +81 868 23 6936.
  • ,
  • Takeo Yokawa

      Affiliations

    • Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan
  • ,
  • Noriyuki Ishihara

      Affiliations

    • Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan
  • ,
  • Tsutomu Okubo

      Affiliations

    • Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan
  • ,
  • Djong-Chi Chu

      Affiliations

    • Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan
  • ,
  • Eri Nishigaki

      Affiliations

    • Faculty of Human Life Science, Mimasaka University, Tsuyama, Okayama 708 8511, Japan
  • ,
  • Yuka Kawada

      Affiliations

    • Faculty of Human Life Science, Mimasaka University, Tsuyama, Okayama 708 8511, Japan
  • ,
  • Masako Kato

      Affiliations

    • Faculty of Human Life Science, Mimasaka University, Tsuyama, Okayama 708 8511, Japan
  • ,
  • Lekh Raj Juneja

      Affiliations

    • Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan

Received 27 April 2009 ,Revised 27 May 2009 ,Accepted 28 May 2009.

References 

  1. Kuo DC, Hsu SP, Chien CT. Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeCl3-induced acute arterial injury in hamsters. J Biomed Sci. 2009;16:15
  2. Yoon SJ, Chu DC, Raj Juneja L. Chemical and physical properties, safety and application of partially hydrolized guar gum as dietary fiber. J Clin Biochem Nutr. 2008;42:1–7
  3. Nakamura S, Hongo R, Moji K, Oku T. Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans. Eur J Clin Nutr. 2007;61:1086–1093
  4. Alam NH, Ashraf H, Sarker SA, Olesen M, Troup J, Salam MA, et al. Efficacy of partially hydrolyzed guar gum-added oral rehydration solution in the treatment of severe cholera in adults. Digestion. 2008;78:24–249
  5. Giannini EG, Mansi C, Dulbecco P, Savarino V. Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome. Nutrition. 2006;22:334–342
  6. Minekus M, Jelier M, Xiao JZ, Kondo S, Iwatsuki K, Kokubo S, et al. Effect of partially hydrolyzed guar gum (PHGG) on the bioaccessibility of fat and cholesterol. Biosci Biotechnol Biochem. 2005;69:932–938
  7. Gallagher AM, Flatt PR, Duffy G, Abdel-Wahab YHA. The effects of traditional antidiabetic plants on in vitro glucose diffusion. Nutr Res. 2003;23:413–424
  8. Yamada K, Tokunaga Y, Ikeda A, Ohkura K, Kaku-Ohkura S, Mamiya S, et al. Effect of dietary fiber on the lipid metabolism and immune function of aged Sprague-Dawley rats. Biosci Biotechnol Biochem. 2003;67:429–433
  9. Maenaka T, Yokawa T, Ishihara N, Gu Y, Juneja LR. Effects of partially hydrolyzed guar gum on postprandial blood glucoselevel and disaccharidase. J Jpn Soc Med Use Func Foods. 2007;4:195–201
  10. Gu Y, yamashita T, Suzuki I, Juneja LR, Yokawa T. Effect of enzyme hydrolyzed guar gum on the elevation of blood glucose levels after meal. Med Biol. 2003;142:19–24
  11. Golay A, Schneider H, Bloise D, Vadas L, Assal J. The effect of a liquid supplement containing guar gum and fructose on glucose tolerance in non–insulin-dependent diabetic patients. Nutr Metab Cardiovasc Dis. 1995;5:141–148
  12. Takahashi T, Karita S, Ogawa N, Goto M. Crystalline cellulose decreases blood glucose increment and stimulates water absorption associated with digesta viscosity in rats. J Nutr. 2005;135:2405–2410
  13. Takahashi T, Sakata T. Insoluble dietary fibers: the major modulator for the viscosity and flow behavior of digesta. Foods Food Ingredients J Jpn. 2005;210:944–953
  14. Japanese Association for Laboratory Animal Science . The guideline for animal experimentation. Exp Anim. 1987;36:285–288
  15. Rutherfurd SM, Moughan PJ. The rat as a model animal for the growing pig in determining ileal amino acid digestibility in soya and milk proteins. J Anim Physiol Anim Nutr (Berl). 2003;87:292–300
  16. Bernabucci U, Bani P, Ronchi B, Lacetera N, Nardone A. Influence of short- and long-term exposure to a hot environment on rumen passage rate and diet digestibility by Friesian heifers. J Dairy Sci. 1999;82:967–973
  17. Takahashi T, Yamanaka N, Sakata T, Ogawa N. Influences of solid particles on the viscous properties of intestinal contents and intestinal tissue weight in rats. J Jpn Soc Nutr Food Sci. 2003;56:199–205
  18. Ishibashi T. In: Doubutsu eiyo jikkenhou Yokendo Ltd. Tokyo. 2001;p. 179
  19. Stephen M, Cummings JH. Water-holding by dietary fiber in vitro and its relationship to fecal output in man. Gut. 1979;20:722–729
  20. Zar JH. Biostatistical analysis. 4th ed.. Engle-wood Clif (NJ): Prentice-Hall Inc; 1999;
  21. Sjöstrand F, Hahn RG. Volume kinetics of glucose 2.5% solution during laparoscopic cholecystectomy. Br J Anaesth. 2004;92:485–492
  22. Takahashi T, Sakaguchi E. Role of the furrow of the proximal colon in the production of soft and hard feces in nutrias, Myocastor coypus. J Comp Physiol B. 2000;170:531–535
  23. Takahashi T, Sakaguchi E. Transport of bacteria across and along the large intestinal lumen of guinea pigs. J Comp Physiol B. 2006;176:173–178
  24. Takahashi T. Chapter 12 Cellulose. In:  Cho SS editors. Handbook of fiber ingredients. Boca Raton: CRC press; 2009;p. 263–282
  25. Antoon CB, Kirsch JF. Investigation of diffusion-limited rates of chymotrypsin reactions by viscosity variation. Biochemistry. 1982;21:1302–1307
  26. Grizard D, Dalle M, Barthomeuf C. Changes in insulin and corticosterone levels may partly mediate the hypolipidemic effect of guar gum and low-molecular weight pectin in rats. Nutr Res. 2001;21:1185–1190

PII: S0271-5317(09)00091-8

doi: 10.1016/j.nutres.2009.05.013

Nutrition Research
Volume 29, Issue 6 , Pages 419-425 , June 2009