Nutrition Research
Volume 29, Issue 10 , Pages 728-735 , October 2009

Reduction of serum lipids by soy protein and soluble fiber is not associated with the ABCG5/G8, apolipoprotein E, and apolipoprotein A1 polymorphisms in a group of hyperlipidemic Mexican subjects

  • Nimbe Torres

      Affiliations

    • Depto de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. 14000, México
    • Corresponding Author InformationCorresponding author. Tel.: +52 55 56553038; fax: +52 55 56553038.
  • ,
  • Martha Guevara-Cruz

      Affiliations

    • Depto de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. 14000, México
  • ,
  • Julio Granados

      Affiliations

    • Depto de Transplantes, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. 14000, México
  • ,
  • Gilberto Vargas-Alarcón

      Affiliations

    • Depto de Fisiología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F. 14000, México
  • ,
  • Berenice González-Palacios

      Affiliations

    • Depto de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. 14000, México
  • ,
  • Victoria E. Ramos-Barragan

      Affiliations

    • Depto de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. 14000, México
  • ,
  • Gabriela Quiroz-Olguín

      Affiliations

    • Depto de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. 14000, México
  • ,
  • Isabel M. Flores-Islas

      Affiliations

    • Depto de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. 14000, México
  • ,
  • Armando R. Tovar

      Affiliations

    • Depto de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. 14000, México

Received 27 July 2009 ,Revised 14 September 2009 ,Accepted 21 September 2009.

References 

  1. Olaiz-Fernández GJ, Rivera-Dommarco J. Encuesta Nacional de Salud y Nutrición. Cuernavaca, Mexico: Instituto Nacional de Salud Pública; 2006;
  2. Expert Panel on Detection E, and Treatment of high blood Cholesterol in Adults . Executive Summary of the Third Report of The National Choelsterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  3. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995;333:276–282
  4. Zhan S, Ho SC. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr. 2005;81:397–408
  5. Gaddi A, Ciarrocchi A, Matteucci A. Dietary treatment for familial hypercholesterolemia-differential effects of dietary soy protein according to the apolipoprotein E phenotypes. Am J Clin Nutr. 1991;53:1191–1196
  6. Jenkins DJA, Kendall CWC, Faulkner DA, Nguyen T, Kemp T, Marchie A, et al. Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. Am J Clin Nutr. 2006;83:582–591
  7. Erdman JW. Soy protein aand cardiovascular disease. A statement for healthcare professionals from the nutrition committee of the AHA. Circulation. 2000;102:2555–2559
  8. Jenkins DJA, Josse RG, Wong JMW. Nguyen T,Kendall CWC. The portfolio diet for cardiovasccular risk reduction. Curr Atheros Rep. 2007;9:501–507
  9. Jenkins DJ, Kendall CW, Marchie A, Faulkner D, Vidgen E, Lapsley KG, et al. The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia. Metabolism. 2003;52:1478–1483
  10. Jenkins DJA, Kendall CWC, Faulkner DA. Effects of a dietary portafolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. JAMA. 2003;290:502–510
  11. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143–3421
  12. Jenkins DJA, Kendall CWC, Mehling CC, Parker TL, Rao AV, Agarwal S, et al. Combined effect of vegetable protein (soy) and soluble fiber added to a standard cholesterol-lowering diet. Metabolism. 1999;48:809–815
  13. Torres N, Tovar AR. Recetario de Soya. México, D.F.: Instituto Nacional de Ciencias Médicas y Nutrición; 2004;
  14. Perez Lizaur AB, Marvan Laborde L, Palacios Gonzalez B. Sistema Mexicano de Equivalentes. Mexico, D.F.: Formento de Nutricion y Salud, A.C.; 2004;
  15. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470–475
  16. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973;19:476–482
  17. Werner M, Gabrielson DG, Eastman J. Ultramicro determination of serum triglycerides by bioluminescent assay. Clin Chem. 1981;27:268–271
  18. Nauck M, Marz W, Wieland H. New immunoseparation-based homogeneous assay for HDL-cholesterol compared with three homogeneous and two heterogeneous methods for HDL-cholesterol. Clin Chem. 1998;44:1443–1451
  19. Friedewal WT, Levy RI, Friedrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  20. Ye SQ, Kwiterovich PO. Influence of genetic polymorphisms on responsiveness to dietary fat and cholesterol. Am J Clin Nutrition. 2000;72(Suppl):1275S–1284S
  21. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215
  22. Kajinami K, Brousseau ME, Nartsupha C, Ordovas JM, Schaefer EJ. ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin. J Lipid Res. 2004;45:653–656
  23. McGuigan FEA, Ralston SH. Single nucleotide polymorphism detection: allelic discrimination using TaqMan. Psychiatric Genet. 2002;12:133–136
  24. Murphy EA. Probability in medicine. Baltimore: Johns Hopkins University Press; 1979;
  25. Feinstein AR. Principles of medical statistics.. Washington (DC): Chapman & Hall/CRC; 2002;
  26. Berge KE, Tian H, Graf GA. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 2000;290:1771–1775
  27. Noriega-Lopez L, Tovar AR, Gonzalez-Granillo M, Hernandez-Pando R, Escalante B, Santillan-Doherty P, et al. Pancreatic insulin secretion in rats fed a soy protein high fat diet depends on the interaction between the amino acid pattern and isoflavones. J Biol Chem. 2007;282:20657–20666
  28. Ascencio C, Torres N, Isoard-Acosta F, Gomez-Perez FJ, Hernandez-Pando R, Tovar AR. Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J Nutr. 2004;134:522–529
  29. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109:1125–1131
  30. Tovar AR, Torre-Villalvazo I, Ochoa M, Elias AL, Ortiz V, Aguilar-Salinas CA, et al. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. J Lipid Res. 2005;46:1823–1832
  31. Matthan NR, Jalbert SM, Ausman LM, Kuvin JT, Karas RH, Lichtenstein AH. Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects. Am J Clin Nutr. 2007;85:960–966
  32. Reynolds K, Chin A, Lees KA, Nguyen A, Bujnowski D, He J. A meta-analysis of the effect of soy protein supplementation on serum lipids. Am J Cardiol. 2006;98:633–640
  33. Jenkins DJ, Kendall CW, Nguyen TH, Marchie A, Faulkner DA, Ireland C, et al. Effect of plant sterols in combination with other cholesterol-lowering foods. Metabolism. 2008;57:130–139

PII: S0271-5317(09)00170-5

doi: 10.1016/j.nutres.2009.09.013

Nutrition Research
Volume 29, Issue 10 , Pages 728-735 , October 2009