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Nutrition Research
Volume 29, Issue 10
, Pages 685-695
, October 2009
Polymorphism of genes encoding homocysteine metabolism–related enzymes and risk for cardiovascular disease
References
- . Folate nutrigenetics: a convergence of dietary folate metabolism, folic acid supplementation, and folate antagonist pharmacogenetics. Drug Metab Lett. 2007;1:55–60
- . Mechanisms of the atherogenic effects of elevated homocysteine in experimental models. Semin Vasc Med. 2005;5:163–171
- . Molecular targeting homocysteine: a mechanism for vascular pathogenesis. Clin Chem Lab Med. 2005;43:1076–1083
- . The role of homocysteine in multisystem age-related problems: a systematic review. J Gerontol A Biol Sci Med Sci. 2005;60:1190–1201
- The Hordaland homocysteine study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr. 2006;136:1731S–1740S
- . The formation of a homologue of cystine by the decomposition of methionine with sulfuric acid. J Biol Chem. 1932;99:135–142
- . The biomedical significance of homocysteine. J Sci Exploration. 2001;15:5–20
- . Homocysteine theory of arteriosclerosis. Atherosclerosis. 1975;22:215–227
- . Hyperhomocysteinemia as a risk factor for occlusive vascular disease. Ann Rev Nutr. 1992;12:279–298
- . Homocysteine, MTHFR gene polymorphisms, and cardio-cerebrovascular risk. J Appl Genet. 2008;49(3):267–282
- . Homocysteine and atherothromobosis. N Engl J Med. 1998;338:1042–1050
- . Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev. 2002;54:599–618
- . Homocysteine as a risk factor for cardiovascular disease: should we (still) worry about it?. Swiss Med Wkly. 2006;136:745–756
- . Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015–2022
- . Hyperhomocysteinemia and thrombosis. Clin Lab Haematol. 1999;22:133–143
- . Homocysteine: the new “cholesterol.” McGraw-Hill Contemporary. 1996;
- . Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003;26:137–146
- Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346:476–483
- . Plasma homocysteine, folate and B12 in chronic schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1289–1296
- . Homocysteine, the vitamin B complex family and bone. Int Congr Series. 2007;1297:151–157
- . Homocysteine-thiolactone and S-nitroso-homocysteine mediate incorporation of homocysteine into protein in humans. Clin Chem Lab Med. 2003;41:1462–1466
- . Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J Nutr. 2001;30:377S–381S
- . Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J. 1999;13:2277–2283
- . The metabolism of homocysteine: pathways and regulation. Eur J Pediatr. 1998;157(Suppl 2):S40–S44
- Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association. Mol Genet Metab. 2005;85:220–227
- . Pathophysiological consequences of homocysteine excess. J Nutr. 2006;136:1741S–1749S
- Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler Thromb Vasc Biol. 2000;20:1704–1706
- Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome. 1998;9:652–656
- A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111–113
- . Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. J Nutr. 1999;129:919–922
- . Recent insights into the molecular genetics of the homocysteine metabolism. Kidney Int Suppl. 2001;59(Suppl 78):S238–S242
- Geographical and ethnic variation of the 677C-T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet. 2003;40:619–625
- . MTHFR polymorphism and bone mineral density: meta-analysis of published studies. Calcif Tissue Int. 2006;79:289–293
- . Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol. 2007;165:1–13
- . 5,10-Methylenetetrahydrofolate reductase 677C→T and 1298A→C mutations are genetic determinants of elevated homocysteine. Q J Med. 2003;96:297–303
- . Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population. Am J Clin Nutr. 2006;83:708–713
- . The methylenetetrahydrofolate reductase 677C→T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism. Am J Hum Genet. 2007;80:846–855
- Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C→T polymorphism, nutrient intake, and incident cardiovascular disease in 24 968 initially healthy women. Clin Chem. 2007;53:845–851
- . Gene–nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population. Thromb Res. 2006;117:501–506
- Methionine synthase reductase 66AG polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate reductase 677CT variant. J Nutr. 2004;134:2985–2990
- . Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event. Mol Genet Metab. 2003;79:201–213
- . The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. Arch Med Res. 2008;39:125–130
- Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease. Am J Cardiol. 2004;93:1201–1206
- Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: the A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal). Thromb Res. 2008;122:648–656
- C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects. J Appl Genet. 2009;50:63–67
- Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. Atherosclerosis. 1999;146:133–140
- Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism–related enzymes, and angiographically proven coronary artery disease. Eur J Intern Med. 2007;18:474–483
- . United Kingdom Childhood Cancer Study Investigators. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci U S A. 2001;98:4004–4009
- A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet. 1998;62:1044–1051
- Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet. 1994;7:195–200
- . Identification of four novel mutations in severe methylenetetrahydrofolate reductase deficiency. Eur J Hum Genet. 1998;6:257–265
- . Methylenetetrahydrofolate reductase deficiency in four siblings: a clinical, biochemical, and molecular study of the family. Am J Med Genet. 2000;91:363–367
- Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L. Am J Hum Genet. 2002;71:143–153
- Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet. 1996;5:1867–1874
- . Human methionine synthase: cDNA cloning, gene localization, and expression. J Biol Chem. 1997;272:3628–3634
- Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis. 2003;166:49–55
- . High prevalence of a mutation in the cystathionine β-synthase gene. Am J Hum Genet. 1996;59:1262–1267
- Defects in human methionine synthase in cblG patients. Hum Mol Genet. 1996;5:1859–1865
- A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Molec Genet Metab. 1999;67:317–323
- . Electron transfer partners of cytochrome P450 cytochrome P450: structure, mechanism, and biochemistry. 3rd ed.. New York: Kluwer Academic/Plenum Publishers; 2005;
- The human cystathionine b-synthase (CBS) gene: complete sequence, alternative splicing, and polymorphisms. Genomics. 1998;52:312–324
- Homocystinuria due to cystathionine beta-synthase deficiency: novel biochemical findings and treatment efficacy. J Inherit Metab Dis. 2003;26:761–773
- The natural history of homocystinuria due to cystathionine β-synthase deficiency. Am J Hum Genet. 1985;31:1–31
- The molecular basis of cystathionine β-synthase deficiency in Dutch patients with homocystinuria: effect of CBS genotype on biochemical and clinical phenotype and on response to treatment. Am J Hum Genet. 1999;65:59–67
- . Structural insights into mutations of cystathionine β-synthase. Biochim Biophys Acta. 2003;1647:206–213
- Hyperhomocysteinemia in premature arterial disease: examination of cystathionine beta-synthase alleles at the molecular level. Hum Mol Genet. 1995;4:623–629
- High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations. Hum Mutat. 2002;19:641–655
- Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. Am J Clin Nutr. 2003;77:1318–1323
- Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am J Clin Nutr. 1999;69:99–104
- . Low-dose folic acid supplementation reduces homocysteine concentration in hyperhomocysteinemic coronary artery disease patients. Nutr Res. 2006;26:460–466
- Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr. 2006;84:361–370
- . Weekly may be as efficacious as daily folic acid supplementation in improving folate status and lowering serum homocysteine concentrations in Guatemalan women. J Nutr. 2008;138:1491–1498
- . Hyperhomocysteinaemia and folic acid supplementation in patients with high risk of coronary artery disease. Indian J Med Res. 2004;119:33–37
- Cardiovascular morbidity and mortality in the atherosclerosis and folic acid supplementation trial (ASFAST) in chronic renal failure. J Am Coll Cardiol. 2006;47:1108–1116
- . Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr. 1994;124:1927–1933
- Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet. 2007;369:208–216
- Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA. 2008;300:795–804
- Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006;354:1578–1588
- Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease. JAMA. 2008;299:2027–2036
- Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients. Stroke. 2006;37:456–460
- . Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354:1567–1577
- . Vitamin and mineral requirements in human nutrition. 2nd ed.. 2004;China
- . Too much folate: a risk factor for cancer and cardiovascular disease?. Curr Opin in Clin Nutr Metab Care. 2009;12:30–36
- . Homocysteine. Farm Współ. 2008;1:169–175
- . Strategies for the treatment of cystathionine β-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years. Eur J Pediatr. 1998;157(S2):S71–S76
- . Treatment of hyperhomocyst(e)inemia: physiological basis. J Nutr. 1996;126:1273S–1275S
- . Genetic variation in genes of folate metabolism and neural-tube defect risk. Proc Nutr Soc. 2006;65:204–215
- . Folic acid in physiology and pathology. Postepy Hig Med Dosw. 2008;62:405–419
- Folate nutritional genetics and risk for hypertension in an elderly population sample. J Nutrigenet Nutrigenomics. 2009;2:1–8
PII: S0271-5317(09)00175-4
doi: 10.1016/j.nutres.2009.09.018
© 2009 Elsevier Inc. All rights reserved.
Next »
Nutrition Research
Volume 29, Issue 10
, Pages 685-695
, October 2009
