Tomato powder is more protective than lycopene supplement against lipid peroxidation in rats

Alshatwi, Ali A.; Al Obaaid, Manal A.; Al Sedairy, Sahar A.; Al-Assaf, Abdullah H.; Zhang, Jun Jun; Lei, Kai Y.

doi:10.1016/j.nutres.2009.12.002

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Volume 30, Issue 1 , Pages 66-73, January 2010

Tomato powder is more protective than lycopene supplement against lipid peroxidation in rats

Ali A. Alshatwi
- Department of Food Science and Nutrition, King Saud University, Riyadh 11451, Saudi Arabia
- Corresponding author. Tel.: +1 301 405 2143; fax: +1 301 314 3313; or Tel.: +996 1 467 7122; fax: +996 1 467 8394.
Manal A. Al Obaaid
- Department of Food Science and Nutrition, King Saud University, Riyadh 11451, Saudi Arabia
Sahar A. Al Sedairy
- Department of Food Science and Nutrition, King Saud University, Riyadh 11451, Saudi Arabia
Abdullah H. Al-Assaf
- Department of Food Science and Nutrition, King Saud University, Riyadh 11451, Saudi Arabia
Jun Jun Zhang
- Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
Kai Y. Lei
- Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
- Center of Excellence for Biotechnology Research, King Saud University, Riyadh 11451, Saudi Arabia
- Corresponding author. Tel.: +1 301 405 2143; fax: +1 301 314 3313; or Tel.: +996 1 467 7122; fax: +996 1 467 8394.

Received 24 August 2009; received in revised form 31 October 2009; accepted 14 December 2009.

Abstract

The hypothesis that tomato powder (TP) is more protective than lycopene-beadlet (LB) treatment in rats fed with or without H₂O₂ was tested by comparing their beneficial effects on serum and hepatic lipids, peroxidation product (malondialdehyde [MDA]), and serum lipoproteins. In groups receiving no H₂O₂, TP and LB similarly lowered MDA, a major lipid peroxidation product, moderately in the serum but markedly in the liver, more than their respective controls. Hydrogen peroxide consumption elevated liver and serum MDA levels similarly among all treatments, but induced no increase in serum MDA for the TP group, which indicated a stronger protection against lipid peroxidation by TP than by LB treatment. Although the TP and LB diets provided equal amounts of lycopene, serum, and liver lycopene levels for treatments with or without H₂O₂, they were markedly elevated in TP but still higher in LB group than controls. This indicated a greater lycopene bioavailability in LB than TP. Importantly, TP and LB treatments with or without H₂O₂ consumption lowered serum total cholesterol and triglycerides by one fifth, as well as decreased serum low-density lipoprotein cholesterol by more than one third of their respective levels in controls. Similarly, liver total cholesterol was markedly lowered (>1/3) by TP or LB treatment, but liver triglycerides were lowered to one fourth by only TP treatment, of the levels in their respective controls. Thus, TP appeared to be more protective because of its additional ability to prevent the H₂O₂-induced rise in serum MDA and seemed to lower liver triglycerides more than LB treatment.