White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats

Jeong, Sang Chul; Jeong, Yong Tae; Yang, Byung Keun; Islam, Rezuanul; Koyyalamudi, Sundar Rao; Pang, Gerald; Cho, Kai Yip; Song, Chi Hyun

doi:10.1016/j.nutres.2009.12.003

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Volume 30, Issue 1 , Pages 49-56, January 2010

White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats

Sang Chul Jeong
- Center for Plant and Food Science, College of Health and Science, University of Western Sydney, Penrith South DC, NSW 1797, Australia
Yong Tae Jeong
- Department of Biotechnology, Daegu University, Gyoungbuk 712-714, South Korea
Byung Keun Yang
- Department of Biotechnology, Daegu University, Gyoungbuk 712-714, South Korea
Rezuanul Islam
- Department of Biotechnology, Daegu University, Gyoungbuk 712-714, South Korea
Sundar Rao Koyyalamudi
- Center for Plant and Food Science, College of Health and Science, University of Western Sydney, Penrith South DC, NSW 1797, Australia
Gerald Pang
- Center for Plant and Food Science, College of Health and Science, University of Western Sydney, Penrith South DC, NSW 1797, Australia
- Corresponding author. Tel.: +61 2 9685 9987 (Office phone); fax: +61 2 9685 9915.
Kai Yip Cho
- Center for Plant and Food Science, College of Health and Science, University of Western Sydney, Penrith South DC, NSW 1797, Australia
Chi Hyun Song
- Department of Biotechnology, Daegu University, Gyoungbuk 712-714, South Korea

Received 19 September 2009; received in revised form 11 November 2009; accepted 14 December 2009.

Abstract

Agaricus bisporus (white button mushroom; WBM) contains high levels of dietary fibers and antioxidants including vitamin C, D, and B₁₂; folates; and polyphenols that may provide beneficial effects on cardiovascular and diabetic diseases. The objective of this study was to examine the hypothesis that intake of the fruiting bodies of WBM regulates anticholesterolemic and antiglycemic responses in rats fed a hypercholesterolemic diet (0.5% cholesterol; 14% fat) and rats with type 2 diabetes induced by injection of streptozotocin (STZ) (50 mg/kg body weight), respectively. The STZ-induced diabetic male Sprague-Dawley rats fed the Agaricus bisporus powder (ABP; 200 mg/kg of body weight) for 3 weeks had significantly reduced plasma glucose and triglyceride (TG) concentrations (24.7% and 39.1%, respectively), liver enzyme activities, alanine aminotransferase and aspartate aminotransferase (11.7% and 15.7%, respectively), and liver weight gain (P < .05). In hypercholesterolemic rats, oral feeding of ABP for 4 weeks resulted in a significant decrease in plasma total cholesterol (TC) and low-density lipoprotein (LDL) (22.8% and 33.1%, respectively) (P < .05). A similar significant decrease in hepatic cholesterol and TG concentrations was observed (36.2% and 20.8%, respectively) (P < .05). Decrease in TC, LDL, and TG concentrations was accompanied by a significant increase in plasma high-density lipoprotein concentrations. It was concluded that A bisporus mushroom had both hypoglycemic and hypolipidemic activity in rats.

Abbreviations: ABP, Agaricus bisporus powder, ALT, alanine aminotransferase, AST, aspartate aminotransferase, BW, body weight, HDL, high-density lipoprotein, LDL, low-density lipoprotein, STZ, streptozotocin, TC, total cholesterol, TG, triglyceride