Nutrition Research
Volume 30, Issue 1 , Pages 74-81 , January 2010

Inhibition by licorice flavonoid oil of glutathione S-transferase–positive foci in the medium-term rat hepatocarcinogenesis bioassay

  • Kaku Nakagawa

      Affiliations

    • QOL Division, Kaneka Corporation, Kita-ku, Osaka 530-8288, Japan
  • ,
  • Kazunori Hosoe

      Affiliations

    • QOL Division, Kaneka Corporation, Kita-ku, Osaka 530-8288, Japan
  • ,
  • Takayoshi Hidaka

      Affiliations

    • Department of Health Sciences and Social Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Chuo-ku, Kobe 650-8586, Japan
  • ,
  • Kyoko Nabae

      Affiliations

    • DIMS Institute of Medical Science, Inc., Azai-cho, Ichinomiya, Aichi 491-0113, Japan
  • ,
  • Mayumi Kawabe

      Affiliations

    • DIMS Institute of Medical Science, Inc., Azai-cho, Ichinomiya, Aichi 491-0113, Japan
  • ,
  • Mitsuaki Kitano

      Affiliations

    • Pharmacology and Toxicology Laboratory, Frontier Biochemical and Medical Research Laboratories, Kaneka Corporation, Takasago, Hyogo 676-8688, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 79 445 2427; fax: +81 79 445 2699.

Received 19 October 2009 ,Revised 5 December 2009 ,Accepted 17 December 2009.

References 

  1. Nakagawa K, Kishida H, Arai N, Nishiyama T, Mae T. Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-Ay mice. Biol Pharm Bull. 2004;27:1775–1778
  2. Aoki F, Honda S, Kishida H, Kitano M, Arai N, Tanaka H, et al. Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice. Biosci Biotechnol Biochem. 2007;71:206–214
  3. Tominaga Y, Mae T, Kitano M, Sakamoto Y, Ikematsu H, Nakagawa K. Licorice flavonoid oil effects body weight loss by reduction of body fat mass in overweight subjects. J Health Sci. 2006;52:672–683
  4. Tominaga Y, Nakagawa K, Mae T, Kitano M, Yokota S, Arai T, et al. Licorice flavonoid oil reduces total body fat and visceral fat in overweight subjects. Obes Res Clin Pract. 2009;3:169–178
  5. Aoki F, Nakagawa K, Kitano M, Ikematsu H, Nakamura K, Yokota S, et al. Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. J Am Coll Nutr. 2007;26:209–218
  6. Nakagawa K, Kitano M, Kishida H, Hidaka T, Nabae K, Kawabe M, et al. 90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats. Food Chem Toxicol. 2008;46:2349–2357
  7. Nakagawa K, Hidaka T, Kitano M, Asakura M, Kamigaito T, Noguchi T, et al. Genotoxicity studies on licorice flavonoid oil (LFO). Food Chem Toxicol. 2008;46:2525–2532
  8. Tamir S, Eizenberg M, Somjen D, Stern N, Shelach R, Kaye A, et al. Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Cancer Res. 2000;60:5704–5709
  9. Lee CK, Park KK, Lim SS, Park JH, Chung WY. Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull. 2007;30:2191–2195
  10. Chin YW, Jung HA, Liu Y, Su BN, Castoro JA, Keller WJ, et al. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). J Agric Food Chem. 2007;55:691–697
  11. Shirai TA. Medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: a historical review of model development and summary of results from 291 tests. Toxicologic Pathology. 1997;25:453–460
  12. Shirai T, Hirose M, Ito N. Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals. In:  Mcgregor DB,  Rice JM,  Venitt S editor. The use of short- and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation. Lyon: IARC; 1999;p. 251–252
  13. Pitot HC, Dragan YP. Chemical carcinogenesis. In:  Klaassen CD editors. Casarett and Doull's toxicology (the basic science of poisons). 6th ed.. NY: McGraw-Hill Medical Publishing Division; 2001;p. 241–319[Chapter 8]
  14. Ito N, Tamano S, Shirai T. A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci. 2003;94:3–8
  15. In: International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use. Testing for carcinogenicity of pharmaceuticals. ICH Harmonised Tripartite Guideline. 1997;
  16. Japanese Association for Laboratory Animal Science . Guideline for animal experimentation. Exp Anim. 1987;36:285–288
  17. Ito N, Hasegawa R, Imaida K, Hirose M, Shirai T. Medium-term rat liver bioassay for rapid detection of hepatocarcinogenic substances. J Toxicol Pathol. 1997;10:1–11
  18. Ito N, Tsuda H, Tatematsu M, Inoue T, Tagawa Y, Aoki T, et al. Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats—an approach for a new medium-term bioassay system. Carcinogenesis. 1988;9:387–394
  19. Sato K, Kitahara A, Satoh K, Ishikawa T, Tatematsu M, Ito N. The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Gann. 1984;75:199–202
  20. Watanabe T, Katsura Y, Yoshitake A. IPAP: Image processor for analytical pathology. J Toxicol Pathol. 1994;7:353–361
  21. Ogiso T, Tatematsu M, Tamano S, Hasegawa R, Ito N. Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis. 1990;11:561–566
  22. Berenblum I. The mechanism of carcinogenesis: a study of the significance of cocarcinogenic action and related phenomena. Cancer Res. 1941;1:807–814
  23. Tatematsu M, Mera Y, Ito N, Satoh K, Sato K. Relative merits of immunohistochemical demonstrations of placental A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis. 1985;6:1621–1626
  24. Hasegawa R, Shirai T, Hakoi K, Takaba K, Iwasaki S, Hoshiya T, et al. Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses. Jpn J Cancer Res. 1991;82:1378–1384
  25. Kitano M, Ichihara T, Matsuda T, Wanibuchi H, Tamano S, Hagiwara A, et al. Presence of a threshold for promoting effects of Phenobarbital on diethylnitrosamine-induced hepatic foci in the rat. Carcinogeneis. 1998;19:1475–1480
  26. Masuda C, Wanibuchi H, Otori K, Wei M, Yamamoto S, Hiroi T, et al. Presence of a no-observed effect level for enhancing effects of development of the α-isomer of benzene hexachloride (α-BHC) on diethylnitrosamine-initiated hepatic foci in rats. Cancer lett. 2001;163:179–185
  27. Ogiso T, Tatematsu M, Tamano S, Tsuda H, Ito N. Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay. Toxicol Pathol. 1985;13:257–265
  28. Tatematsu M, Mera Y, Inoue T, Satoh K, Ito N. Stable phenotypic expression of glutathion S-transferase placental type and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions. Carcinogenesis. 1988;9:215–220
  29. Hosokawa S, Tatematsu M, Aoki T, Nakanowatari J, Igarashi T, Ito N. Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator. Carcinogenesis. 1989;10:2237–2241
  30. Takekoshi H, Mizoguchi T, Komasa Y, Chubachi H, Inoue Y, Imanishi H, et al. Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa. Oncol Rep. 2005;14:409–414
  31. Ohnishi H, Asamoto M, Tujimura K, Hokaiwado N, Takahashi S, Ogawa K, et al. Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo. Cancer Sci. 2004;95:936–942
  32. Shukla Y, Arora A. Suppression of altered hepatic foci development by curcumin in Wistar rats. Nutr Cancer. 2003;45:53–59
  33. Ichihara T, Wanibuchi H, Taniyama T, Okai Y, Yano Y, Otani S, et al. Inhibition of liver glutathione S-transferase placental form-positive foci development in the rat hepatocarcinogenesis by Porphyra tenera (Aswakusa-nori). Cancer Lett. 1999;141:211–218
  34. Samaranayake MD, Wickramasinghe SM, Angunawela P, Jayasekera S, Iwai S, Fukushima S. Inhibition of chemically induced liver carcinogenesis in Wister rats by garlic (Allium sativum). Phytother Res. 2000;14:564–567
  35. Takada N, Matsuda T, Otoshi T, Yano Y, Otani S, Hasegawa T, et al. Enhancement by organosulfur compounds from garlic and onions of diethylnitrosamine-induced glutathione S-transferase positive foci in the rat liver. Cancer Res. 1994;54:2895–2899
  36. Fukushima S, Takada N, Hori T, Wanibuchi H. Cancer prevention by organosulfur compounds from garlic and onion. J Cell Biochem Suppl. 1997;27:100–105
  37. Uda N, Kashimoto N, Sumioka I, Kyo E, Sumi S, Fukushima S. Aged garlic extract inhibits development of putative preneoplastic lesions in rat hepatocarcinogenesis. J Nutr. 2006;136(3 Suppl):855S–860S
  38. Lee CK, Son SH, Park KK, Park JH, Lim SS, Chung WY. Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. J Pharmacol Sci. 2008;106:444–451

PII: S0271-5317(09)00255-3

doi: 10.1016/j.nutres.2009.12.005

Nutrition Research
Volume 30, Issue 1 , Pages 74-81 , January 2010