Nutrition Research
Volume 30, Issue 6 , Pages 392-395 , June 2010

Chitosan improves insulin sensitivity as determined by the euglycemic-hyperinsulinemic clamp technique in obese subjects

  • Sandra O. Hernández-González

      Affiliations

    • Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, 44349 Guadalajara, Mexico
    • ,
  • Manuel González-Ortiz

      Affiliations

    • Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, 44349 Guadalajara, Mexico
    • Cardiovascular Research Unit, Physiology Department, Health Science University Center, University of Guadalajara, 44380 Guadalajara, Mexico
    • Corresponding Author InformationCorresponding author. Montes Urales 1409, Colonia Independencia, 44340, Guadalajara, Mexico. Tel.: +52 33 38267022; fax: +52 33 36161218.
    • ,
  • Esperanza Martínez-Abundis

      Affiliations

    • Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, 44349 Guadalajara, Mexico
    • Cardiovascular Research Unit, Physiology Department, Health Science University Center, University of Guadalajara, 44380 Guadalajara, Mexico
    • ,
  • José A. Robles-Cervantes

      Affiliations

    • Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, 44349 Guadalajara, Mexico

Received 13 April 2010 ,Revised 4 June 2010 ,Accepted 8 June 2010.

References 

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  2. Rucker D, Padwal R, Li SK, Curioni C, Lau DC. Long-term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ. 2007;335:1194–1199
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  6. Jull AB, Ni Mhurchu C, Bennett DA, Dunshea-Mooij CA, Rodgers A. Chitosan for overweight or obesity. Cochrane Database Syst Rev. 2008;3:CD003892
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  8. Jacques-Camarena O, González-Ortiz M, Martínez-Abundis E, López-Madrueño JFP, Medina-Santillán R. Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance. Ann Nutr Metab. 2008;53:195–198
  9. Jeyaseelan L, Rao P. Methods of determining sample size in clinical trials. Indian Pediatr. 1989;26:115–121
  10. González-Ortiz M, Martínez-Abundis E, Jacques-Camarena O, Hernández-González SO, Valera-González IG, Ramos-Zavala MG. Prevalence of metabolic syndrome in adults with excess of adiposity: comparison of the Adult Treatment Panel III criteria with the International Diabetes Federation definition. Acta Diabetol. 2006;43:84–86
  11. Forst T, Hohberg C, Pfützner A. Cardiovascular effects of disturbed insulin activity in metabolic syndrome and in type 2 diabetic patients. Horm Metab Res. 2009;41:123–131
  12. Hayashi K, Ito M. Antidiabetic action of low molecular weight chitosan in genetically obese diabetic KK-Ay mice. Biol Pharm Bull. 2002;25:188–192
  13. Lee HW, Park YS, Chol JW, Yi SY, Shin WS. Antidiabetic effects of chitosan oligosaccharides in neonatal streptozotocin-induced noninsulin-dependent diabetes mellitus in rats. Biol Pharm Bull. 2003;26:1100–1103
  14. Pittler MH, Ernst E. Dietary supplements for body-weight reduction: a systematic review. Am J Clin Nutr. 2004;79:529–536
  15. Bougoulia M, Triantos A, Koliakos G. Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women. Hormone. 2006;5:259–269

PII: S0271-5317(10)00103-X

doi: 10.1016/j.nutres.2010.06.005

Nutrition Research
Volume 30, Issue 6 , Pages 392-395 , June 2010

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