Nutrition Research
Volume 30, Issue 6 , Pages 418-426 , June 2010

Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice

  • Kylie Kavanagh

      Affiliations

    • Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    • Corresponding Author InformationCorresponding author. Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine Medical Center Blvd., Winston-Salem, NC 27157, USA. Tel.: +1 336 716 1555; fax: +1 336 716 1515.
  • ,
  • Soraya Sajadian

      Affiliations

    • Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
  • ,
  • Kurt A. Jenkins

      Affiliations

    • Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
  • ,
  • Martha D. Wilson

      Affiliations

    • Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
  • ,
  • J. Jeffery Carr

      Affiliations

    • Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
  • ,
  • Janice D. Wagner

      Affiliations

    • Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
  • ,
  • Lawrence L. Rudel

      Affiliations

    • Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA

Received 16 April 2010 ,Revised 4 June 2010 ,Accepted 7 June 2010.

References 

  1. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109:433–438
  2. Singhal A, Lucas A. Early origins of cardiovascular disease: is there a unifying hypothesis?. Lancet. 2004;363:1642–1645
  3. Dunger DB, Salgin B, Ong KK. Session 7: early nutrition and later health early developmental pathways of obesity and diabetes risk. Proc Nutr Soc. 2007;66:451–457
  4. Mozaffarian D, Pischon T, Hankinson SE, Rifai N, Joshipura K, Willett WC, et al. Dietary intake of trans fatty acids and systemic inflammation in women. Am J Clin Nutr. 2004;79:606–612
  5. Salmeron J, Hu FB, Manson JE, Stampfer MJ, Colditz GA, Rimm EB, et al. Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr. 2001;73:1019–1026
  6. Craig-Schmidt MC. World-wide consumption of trans fatty acids. Atheroscler Suppl. 2006;7:1–4
  7. Kavanagh K, Jones KL, Sawyer J, Kelley K, Carr JJ, Wagner JD, et al. Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Obesity (Silver Spring). 2007;15:1675–1684
  8. Gartner LM, Morton J, Lawrence RA, Naylor AJ, O'Hare D, Schanler RJ, et al. Breastfeeding and the use of human milk. Pediatrics. 2005;115:496–506
  9. Elias SL, Innis SM. Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. Am J Clin Nutr. 2001;73:807–814
  10. Larque E, Zamora S, Gil A. Dietary trans fatty acids in early life: a review. Early Hum Dev. 2001;65(Suppl):S31–S41
  11. Craig-Schmidt MC, Weete JD, Faircloth SA, Wickwire MA, Livant EJ. The effect of hydrogenated fat in the diet of nursing mothers on lipid composition and prostaglandin content of human milk. Am J Clin Nutr. 1984;39:778–786
  12. Innis SM. Trans fatty intakes during pregnancy, infancy and early childhood. Atheroscler Suppl. 2006;7:17–20
  13. Innis SM, King DJ. Trans fatty acids in human milk are inversely associated with concentrations of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast-fed infants. Am J Clin Nutr. 1999;70:383–390
  14. Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? Estimating the progression and cost of the U.S. obesity epidemic. Obesity (Silver Spring). 2008;16:2323–2330
  15. Koh-Banerjee P, Chu NF, Spiegelman D, Rosner B, Colditz G, Willett W, et al. Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 U.S. men. Am J Clin Nutr. 2003;78:719–727
  16. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, et al. Origins and evolution of the western diet: health implications for the 21st century. Am J Clin Nutr. 2005;81:341–354
  17. Waterland RA, Travisano M, Tahiliani KG, Rached MT, Mirza S. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond). 2008;32:1373–1379
  18. Knight CH, Maltz E, Docherty AH. Milk yield and composition in mice: effects of litter size and lactation number. Comp Biochem Physiol A Comp Physiol. 1986;84:127–133
  19. Metcalfe LD, Schmitz AA, Pelka JR. Rapid preparation of fatty acid esters from lipid gas chromatography analysis. Anal Chem. 1966;38:514–515
  20. Heikkinen S, Argmann CA, Champy MF, Auwerx J. Evaluation of glucose homeostasis. Curr Protoc Mol Biol. 2007;Chapter 29:Unit 29B;3.1-3.22
  21. Aoki N, Yamaguchi Y, Ohira S, Matsuda T. High fat feeding of lactating mice causing a drastic reduction in fat and energy content in milk without affecting the apparent growth of their pups and the production of major milk fat globule membrane components mfg-e8 and butyrophilin. Biosci Biotechnol Biochem. 1999;63:1749–1755
  22. Koletzko B. Trans fatty acids may impair biosynthesis of long-chain polyunsaturates and growth in man. Acta Paediatr. 1992;81:302–306
  23. Bayol SA, Farrington SJ, Stickland NC. A maternal ‘junk food’ diet in pregnancy and lactation promotes an exacerbated taste for ‘junk food’ and a greater propensity for obesity in rat offspring. Br J Nutr. 2007;98:843–851
  24. Armitage JA, Taylor PD, Poston L. Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. J Physiol. 2005;565:3–8
  25. McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 2005;85:571–633
  26. Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB. Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ. 2000;320:967–971
  27. Prior LJ, Velkoska E, Watts R, Cameron-Smith D, Morris MJ. Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect?. Int J Obes (Lond). 2008;32:1585–1594
  28. Bayol SA, Simbi BH, Bertrand JA, Stickland NC. Offspring from mothers fed a ‘junk food’ diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females. J Physiol. 2008;586:3219–3230
  29. Vickers MH, Ikenasio BA, Breier BH. IGF-1 treatment reduces hyperphagia, obesity, and hypertension in metabolic disorders induced by fetal programming. Endocrinology. 2001;142:3964–3973
  30. Holly J, Sabin M, Perks C, Shield J. Adipogenesis and IGF-1. Metab Syndr Relat Disord. 2006;4:43–50
  31. Li C, Kaur H, Choi WS, Huang TT, Lee RE, Ahluwalia JS. Additive interactions of maternal prepregnancy BMI and breast-feeding on childhood overweight. Obes Res. 2005;13:362–371
  32. Enig MG, Atal S, Keeney M, Sampugna J. Isomeric trans fatty acids in the U.S. diet. J Am Coll Nutr. 1990;9:471–486
  33. Muskiet FA, van Goor SA, Kuipers RS, Velzing-Aarts FV, Smit EN, Bouwstra H, et al. Long-chain polyunsaturated fatty acids in maternal and infant nutrition. Prostaglandins Leukot Essent Fatty Acids. 2006;75:135–144
  34. Mosley EE, Wright AL, McGuire MK, McGuire MA. Trans fatty acids in milk produced by women in the United States. Am J Clin Nutr. 2005;82:1292–1297
  35. Szabo E, Boehm G, Beermann C, Weyermann M, Brenner H, Rothenbacher D, et al. Trans octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: results of a large birth cohort study. Am J Clin Nutr. 2007;85:1320–1326
  36. Teter BB, Sampugna J, Keeney M. Lactation curves and effect of pup removal on milk fat of C57BL/6J mice fed different diet fats. Lipids. 1992;27:912–916
  37. Wainwright PE. Issues of design and analysis relating to the use of multiparous species in developmental nutritional studies. J Nutr. 1998;128:661–663

PII: S0271-5317(10)00104-1

doi: 10.1016/j.nutres.2010.06.006

Nutrition Research
Volume 30, Issue 6 , Pages 418-426 , June 2010